Science topics: Medicine
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Medicine - Science topic

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Questions related to Medicine
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For example , instead of heart beating so fast = Palpitations
Faint, pass out = Pre-syncope
What is this process called (Translation of what the patient describes into medical terminology) so I can study it more efficiently and search more info.about it?
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It is not as straightfoward as translation but with patients description and looking at standard medical definitions of symptoms we can transcribe was patients describe into medical terminology.
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Dear fellow researchers,
My institution has recently requested our research team to perform a meta-analysis on a random topic related to finances/economy and drug market. Having our previous work done in a dramatically discrepant field, we are unfortunately unaware of the modern trends/common themes of research on the given topics. We would highly appreciate any possible input on a potential topic to direct our research: what are the recent trends of studies in the field of drug economy/marketing?
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Milena Miljkovic (miljkovic.milena57@yahoo.com)
The new ISPOR Report: “Trends in Health Economics & Outcomes Research” that describes 2019’s top 10 trends in the applications of Health Economics and Outcomes Research (HEOR), is availablend at:
The below specified publication sets forth a research agenda for better measurement of certain elements of value not normally captured in costeffectiveness analysis and related approaches.
Garrison LP Jr, Neumann PJ, Willke RJ, Basu A, Danzon PM, Doshi JA, Drummond MF, Lakdawalla DN, Pauly MV, Phelps CE, Ramsey SD1, Towse A, Weinstein MC. A Health Economics Approach to US Value Assessment Frameworks-Summary and Recommendations of the ISPOR Special Task Force Report [7]. Value Health. 2018 Feb;21(2):161-165. doi: 10.1016/j.jval.2017.12.009.
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I'd like to get opinions of experts or people who uses CIR system or LOOP or other way to map medical curricula
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Thanks but says page not found
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When you prescribe a medication, what is your go-to-site/book/reference to check for adverse reactions? And what type of adverse reactions do you check? Is it type A adverse reactions only that you check?
And in other words: what are the most important adverse reactions that you must check?
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Several:
1. Package insert
2. Physician Desk Reference
3. Online resources of FDA
4. Review published peer-reviewed journal articles
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54 Y Female who will undergo vaginal hysterectomy along with some issues in the anal canal and bladder.
Medical History:
Atrial Fibrillation (Managed by Bisoprolol 2.5 mg once daily)
Chronic venous insufficiency (Managed by Daflon one tablet once daily)
Allergic Rhinitis (Managed by Cetirizine 10 mg once daily)
Non alcoholic fatty liver disease
Past (maybe relevant history) - She went 2 years ago to the ICU because she lost abnormal amounts of blood along with AFib episode which required blood transfusion, during her stay in the ICU, some symptoms and abnormalities occurred like Fever and Superficial thrombophlebitis.
Beside this, some signs and symptoms that the cardiologist agreed not to investigate the cause and there is no need to (After he investigated the Echocardiogram, Blood pressure, ECG : Occassional dyspnea, some symptoms that mimic coronary artery disease like Chest pain.
The Anesthesiologist plan according to this history and CBC and some questions that I can post answers to if you asked them:
General Anesthesia and she shouldn't discontinue Daflon and should take Enoxaparin two days consequently prior to the surgery.
My Q is, is prophylaxis using Enoxaparin considered to be good? Also what about Daflon, should she continue using it? Final one, does she need to stop dietary garlic 7 days prior to the surgery because the Anesthesiologist forgot to mention this one ?
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All,
Do we not encounter this problem daily or weekly? How long do we have between preoperative evaluation and DOS? Are we seeing the patient in the preoperative holding area? Time is the key in planning but not necessarily a game stopper if seen morning of surgery. If seen a week or more ahead, I concur with previous answers. If seen the morning of, GETA (probably TIVA) . Is this laparoscopic assisted? If so, bilateral erector spinae plane blocks for postoperative pain control.
Regards,
Christopher
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Cons and pros of of Neurotoxins and Facial Fillers, your experience especially in young age.
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Side effects of facial fillers
Common side effects
According to the AAD, the following side effects — which tend to occur around the injection site — can be immediate, but usually clear within 7 to 14 days:
  • redness
  • swelling
  • pain
  • bruising
  • itching
  • rash
Rare side effects
While less common, you should be aware of the following side effects:
  • infection
  • leakage of the filler through the injection site
  • nodules around the injection site, which may need to be surgically removed
  • granulomas, a type of inflammatory reaction to the filler
  • movement of the filler from one area to another
  • injury to blood vessels
  • blindness, which occurs when the filler gets injected into an artery, blocking blood flow to the eyes
  • tissue death, again due to blocked blood flow
source
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description of plasma jet in bio medicine.
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ooth bleaching is a common cosmetic dental treatment worldwide for tooth discoloration. Extrinsic discoloration of the teeth results from the deposition of external stain-causing materials, such as tobacco, tea, and coffee, on the tooth surface. Most tooth-bleaching methods primarily use compounds containing hydrogen peroxide (H2O2) or carbamide peroxide to remove these extrinsic stains. These bleaching compounds are usually used with catalytic agents such as light emission and lasers. However, compounds containing H2O2 may cause enamel damage, irritation, and gingivitis; moreover, using a laser also can cause even more severe symptoms. Therefore, seeking a new catalytic agent for tooth bleaching is an important issue. The atmospheric-pressure plasma jet (APPJ) is cost effective and portable and has been proven to be effective and safe for tooth bleaching.
Plasma has been widely used in industrial applications and numerous studies have revealed that low-temperature APPJ (approximately body temperature) can stimulate wound healing, induce cancer cell apoptosis, sterilize bacteria, and decompose tooth stains as well. However, air plasma produces toxic gases such as ozone. Both disadvantages reduce the feasibility of oral APPJ treatment considerably.Thus, to avoid enamel damage and gingivitis and produce lower amounts of toxic gas, a team of scientists from the Department of Mechanical Engineering of the National Chiao Tung University (Taiwan) took an APPJ using helium with saline to perform tooth bleaching. Using this method much lower amounts of toxic gas were produced compared with the air plasma method. In addition, H2O2 gel was replaced with saline solution to reduce enamel damage and gingivitis. Scanning electron microscopy images showed that the tooth surface after He-APPJ treatment was much smoother than that after H2O2 gel treatment, indicating that the He-APPJ was less harmful than H2O2 gel to the enamel. “The results of temperature measurements of the tooth surface, 21.5?°C, and jet, 33?°C, after 20?min of treatment showed that the He-APPJ should not be harmful to the human body as well” says team member Professor J. Wu. In conclusion, the He-APPJ is a safe, promising, and portable tooth bleaching solution.
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Ive been researching this topic since a while and I would love to expand my knowledge in this area, Ive come across some studies claiming that selenium is effective in treating thyroid dysfunctions, and of course iodine, but I would love to know more.
Thank you in advance!
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Dear RG members
thyroid dysfunction is heterogeneous and with mutifactorial etiology, you talk about nutritional deficiency in oligoelements but we have the autoimmune factor, which is the main one (hypothyroidism and hyperthyroidism = baseball disease and hashimoto). In case of thyroiditis of autoimmune the contribution of elements or oligoelements is not significant because of the genetic factor (DR3) many patients control the hormonal balance (TSH, T3 or T4)and they underestimated the autoimmune factor.
nevertheless taking Omega-3 Fish Oil. will positively activate the immune response and inhibit the effect of autoantibodies
BEST REGARDS
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I need it for my research on evidence based medicine in Local context.
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This site will not let me send a link
olease contact me directly and I will forward it.
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There is a uterine prolapse (Last degree) and there is an ulcer. The Q is how can the patient apply the cream prescribed for the ulcer along with the antiseptic and Gauze (Also Vaseline is prescribed).
Is the cream (Mebo cream aids in healing) applied on the ulcer only?, and we impregnate the gauze with the antiseptic (Betadine) and apply it on the cervix and the vagina only, or apply it on the entire prolapsed uterus, and if so, how? Because as we previously applied the cream on the ulcer, so there will be overlapping of two ingredients (Mebo and Betadine) ? And finally how we raise the uterus with the Gauze?
I downloaded the image for illustration.
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Recommended treatment. For decubitus ulcer includes
1. Reduction
2. Ring pessary
3. Estrogen cream
Without pesaary there will be no improvement due to persistent cause which is tiusse necrosis.
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To fight the disease effectively, researchers from across the scientific spectrum and beyond must join forces.
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I say yes.............
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Excuse my naive experience in this area.
Lets assume we have a patient with 2nd degree hemorrhoids, and we want to apply topical product to reduce the swelling of hemorrhoids, do we apply the product on the hemorrhoids after it prolapse or we wait till it return to its position spontaneously then we apply using an applicator? I mean the proper timing for the application of the product.
Second scenario, we have a patient with third degree hemorrhoids, will we apply the product on the prolapsed hemorrhoids or we reduce it manually then we apply the product afterwards using the applicator?
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Hi
Really speaking
I am not believing in topical agents in curing haemorrhoids,neither prolapsed nor 3rd degree haemorrhoids...
Manual reduction is better for relieving the pain and discomfort...
Some drugs stop bleeding like DAFLON
Some cryo therapy may cure the problem like ANOCRYO
SURGERY is still the best,if it is associated with mild-moderate rectal prolapse....
Regards to all.
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Drug from Pfizer, design from Pfizer, researchers from Pfizer, statisticians from Pfizer and the result: drug works well!
It is not necessary to read whole manuscript!
"Maurer MS, Schwartz JH, Gundapaneni B, Elliott PM, Merlini G, Waddington-Cruz M, Kristen AV, Grogan M, Witteles R, Damy T, Drachman BM, Shah SJ, Hanna M, JudgeDP, Barsdorf AI, Huber P, Patterson TA, Riley S, Schumacher J, Stewart M, Sultan MB, Rapezzi C; ATTR-ACT Study Investigators. Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy. N Engl J Med. 2018 Sep 13;379(11):1007-1016. doi: 10.1056/NEJMoa1805689."
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Dear Mesut
I have started to believe that there is politics to reach.
Journals define best articles, best articles get featured and attract systematic reviews and attract citations, get published in these journals and raise their impact (making them best). A phenomenon of you scratch my back, i scratch yours.
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Dear Colleagues,
A plant-based diet is a diet based on fruits, vegetables, whole grains, and legumes while a vegan diet is strictly against all animal products. Whats your openion about PBD and vegan and their effects on our health?
Thanks
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Plant Based Diets (PBDs), including vegan and vegetarian diets, are based around fruits, vegetables, grains, and legumes have been associated with weight loss, a lower prevalence of hypertension and diabetes, and a reduced risk of heart disease. Moreover, studies indicates that a PBDs may be beneficial in the treatment of several chronic diseases such as rheumatoid arthritis. Vegan diet reduces the risks of cancer. Please take a look at the following RG links for more details.
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Which is the better for the researcher, studying various topics and making a research for each one, or studying one particular topic and making a series of researches related to it?
Please reply, and share us your opinions about the discussion
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I would like to thank all researchers for their sincerely opinions, it is very useful to me.
Best Regards
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Some researchers believe that economics has nothing to do with values. It is a neutral science. There is no difference between those who buy chemical materials to make a Medicine or make explosives. The economy looks at the relationship between the quantities required and prices
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Ya?ar Alkan to you as well my friend.
Best Regards
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The thought behind this diet is to cut out foods that cause your body to produce acid ; including meat, wheat, refined sugar, processed foods, dairy, eggs, canned food, packaged snacks, caffeine and alcohol. The Alkaline diet encourage of most fruits and vegetables, nuts, legumes, soybeans and tofu. These are foods that are alkaline;?that have a pH value of 7 or above.
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I think normal daily consumption dose not require any alkaline diets because organism already adopted in daily conditions. If you start alkaline diet it means you will change normal acid base balance which will require daily intervention.
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I want to have ideas for a phD research about biotechnology related with medicine.
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Hi,
The viurs genetic is good field
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The ketogenic diet has gained popularity as a natural way to lose weight and improve health. The diet is very low in carbohydrates, high in fat and moderate in protein. While the diet is considered safe for most people, it’s associated with some unpleasant side effects.
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Keto flu can be avoided by consuming more electrolytes and fats, adding more salt to diet, drinking chicken broths, doing moderate exercise and staying hydrated. Moreover, addition of prebiotics and probiotics to diet are also helpful in avoiding the keto flu.
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Will TRIPS-Plus provisions such as patent linkage, patent term restoration and data exclusivity affect access to medicine?
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Marcella, we share the same view. Im just highlighting the view of some who says protection is good for R&D, innovation etc (including investment). I also haven't found any studies saying so. But some claim so. This claim of others for example was highlighted by a prominent Professor (Joan Rovira) in his paper. This is the link in 1 of the paper: https://www.ictsd.org/sites/default/files/event/2009/01/impact20of20iprversion_rovira1.pdf
Thank you. Many literatures examine the impact on access to medicine, but none that I know on FDI.
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In my country, the benefit from a specific paper is proportional according to the sequence of the researcher’s name in the paper, where (100%, 80% and 70%) for the first, the second and the third researcher respectively, and if there are additional researchers, then they will not get any benefit from the research.
Please reply, share us your opinions about the discussion
Thanks
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With you, son of my country, in the same case. I am looking with you, to dear colleagues contributions .
Regards.
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- I am currently doing a research that mainly tests the influence of problem-based learning system on self-directed learning readiness of medical students. Two groups of medical students (PBL, nonPBL) will be identified and their SDLR will be measured. I think that unpaired t-test is most appropriate for such issue, am I right?
Also, in the same research, I am going to correlate SDLR to the academic year of the participants, and in this case, three groups (year 1, 3, 5) will be identified. I think that ANOVA and post hoc are most appropriate, am I right?
Also, I am going to correlate SDLR with academic performance (grades), but I'm not sure which is most appropriate, Pearson's r maybe?
hopefully someone answers soon.
Thanks in advance.
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Yes, if the distributions of your scores are all nornal, all the tests you considered are suitable.
However, as the scores of your sample may not be normally distributed nor you can assume the scores of your population are normally distributed, I would suggest you to report both the results of the parametric tests (i.e. the ones you considered) and the non-parametric tests (i.e. Mann–Whitney U, Kruskal–Wallis test and Spearman r).
If the p-values of both parametric and non-parametic tests (say, t-test and Mann–Whitney U) are on the same side (say, both <0.05), you can give a definite answer. However, if they are inconsitant, you should give a conservative answer. However, what is "the conservative answer" is sistuational, it idoes not always mean "not significant".
Anyway, you are on the right track, no need to worry at the moment.
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In August 2018, Harvard Health publishing (Harvard Medical School) have been updated old news about the efficiency of drugs activities after their expiry dates.
The question of our discussion is: Does the expiry date of the medicinal drugs is a myth?!
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We carry out many stability studies. Indeed, there are always formation of degradation products which are not part of the original molecule. They might be toxic or not, but it is always better do not risk your health with expired drugs.
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There are wide differences in the template from one journal to another, why this differences, do you agree that the template of the journals should be unified or not? Why
Please share us your opinions
Thanks
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I do not think that magazines are interested in what the researcher wants because the magazines are the strongest authority and researcher is the one who needs them. There are no weaker dictates conditions on the strongest! In addition to the magazines run by different companies with different directions and visions.
Best Regards.
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Would you describe it as brown? And if so does this mean that purpura preceded this color? And what could be the differential diagnosis of this color?
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It's always difficult to analyse isolate images and better to the physician if you see the patient directly.
This lesions remember me scleroderma, but would be interesting after correct inspection you feel the skin through palpation.
It looks like the salt and pepper skin common in scleroderma. The following article published in new england journal of medicine reveal a similar finding. But be carefully, It is importante to evaluate this findings with the laboratory and patients' anamnesis.
Another important differential diagnosis would be the relationship with peripheral arteriovenous insufficiency which can cause a very similar findings.
Cicatricial findings due other types of dermatitis may also be a possibility.
Hope i could help,
Best regards,
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I'm currently doing some work looking at how reliable undergraduate admissions interviews are at selecting the best undergraduates. There is a lot of literature in the field of medicine, in particular looking at MMI approaches, but I was wondering if anyone was aware of anything more general or relating to other subjects?
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Dear Ellie
Your question is very timely, the number of candidates is growing and society, in this sense, demands an attachment to equity, to justice.
In my opinion, interviews can be one more way, but, as colleague Marianne affirms, it may not be free of a subjective component.
A more just and objective way are the entrance exams.
I can tell you that, in my country, they have a mandatory nature and are programmed at the state level.
It is an event of great social importance and is increasingly incorporated into our culture:
regards
Reinaldo
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How can you decide the judgment on a specific article whether it is good or not, is your judgment depends on the title of the article or the abstract or the publishing journal or something else?
Please, share us your opinions about the discussion
Thanks
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several items :
Title
Sample size
Methodology
And the Journal .
Regards
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The software would for example model the effects of changes in blood pressure, heart rate and rhythm, skin colour change, in response to various interventions such a drug administration, change in posture, blood loss etc...
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We have a great software solution that has been integrated into both software and hardware at https://pulse.kitware.com/
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Steatosis , occurs in more than 50% of patients with chronic hepatitis C, that is related to visceral adiposity and obesity. Moreover, Weight loss in patients with chronic hepatitis C may be associated with a reduction in steatosis and abnormal liver enzymes and an improvement in fibrosis. So my question May weight reduction provide a proper response for treatment of patients with chronic C ?
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Hi,
The following article might answer your query
Impact of Obesity on Treatment of Chronic Hepatitis C . HEPATOLOGY 2006;43:1177-1186.
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Stem cell research is a long-standing subject. Quite a lot is known for stem cells. But their massive use in medicine is a novelty of recent times. This area of medicine is developing rapidly. Appears many clinics in various countries around the world. Clinics promise a solution to many problems. It begins with the rejuvenation of the body. Everyone wants to rejuvenate for 5 - 10 - 15 years. Why not? The declarations end with the promise of treating a large number of diseases that were previously considered not measurable. How to get correct information on the current level of development of stem cell medicine? What are the proportions of science, commerce and mythology in modern knowledge about stem cells and their use for medical purposes?
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Page of History. The term itself was introduced in 1909. As far as I know, Alexander Maksimov used the term first (Maximow A. Der Lymphozyt als gemeinsame Stammzelle der verschiedenen Blutelemente in der embryonalen Entwicklung und im postfetalen Leben der S?ugetiere. Originally in: Folia Haematologica 8.1909, 125—134. Republished in: Cell Ther Transplant. 2009,1:e.000040.01. doi: 10.3205/ctt-2008-en-000040.01
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Why scientists must share their failures
Failure moves research forwards
4th May 2017
We don’t ask people in other professions to do it, but it’s vital for speeding up progress in crucial areas of research from climate to medicine and public health
By Ijad Madisch
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I agree with Iman Hassan Ibrahim
Sometimes "failure" is more important and beneficial than success.
If I did not leave the university, I could not get my first research outcome to be published in one of the top journals:
This is because I would stop my remained work and just be graduated from the university to get a PhD. As such, innovation very often follows a significant failure/challenge.
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In the early years of the development of medical specialization, in 1923, Francis Weld Peabody said that patients got confused and did not know to apply to which branch as a result of specialization in medical disciplines; he emphasized that there should be a specialization branch that would take patients as a whole, but this warning did not attract much attention at that time. Studies on this view have only begun after the Second World War, and the beginning of specialization training of medicine has been in following years. On this issue, "General Health Specialization" had been placed in legal regulation of medicine at 1947 in Turkey and education of assistants began, but this educational process did not succeed. Then, training of specialization in medicine had been added to agenda with the stream of Alma-Ata Conference in 1978 and it took part in legal regulation under the name of “Family Medicine Specialization” with firstly its education and then its practise in Turkey in 1983.
The year 1947 can be considered as a starting year of training of specialization in Primary Health Care for Turkey. When did training of specialization in Primary Health Care start in other countries and especially in your own country?
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ünlüo?lu ?., Ayranc? ü., Turkey in Need of Family Medicine, Primary Care, 3: 988-994, 2003.
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Does organic medicine trending due to consumer awared terminologies like 'organic, Natural, No excipients etc.). Does organic herbal medicine have any huge differences/ advantage with normal herbal medicines?
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Yes. Organic medicines of organic manure production have good values. As these are free from pesticides.
All drugs are not replaced by herbal drugs. We have to find out herbal products which can replace commonly used medicine.
Which is comparatively time consuming process.
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Sometimes during preparing for a specific research, the results which obtained may be unsatisfactory or negative, what will you do in such case?
Please, share us your sincerely opinions
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Dear Dr. Mohammed,
It would be frustrating. I will try to modify the research idea or publish the negative results as they are. Negative results may help other researchers not to try again in the same way.
Regards
Rama
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Plasma jet in bio medicine
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Thank you sir for your help.
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In recent years, ecological innovations have also been created on the basis of other non-ecology science. Ecological innovations are mainly created, among others, in the field of renewable energy sources, improvement of waste segregation techniques, recycling, treatment of polluted water, reclamation of a devastated natural environment, energy-efficient construction, electromobility etc. However, more and more eco-innovations, new technological solutions, technical improvements that fit in sustainable pro-ecological economic development also arises in many other fields of science.
In view of the above, are examples of pro-ecological undertakings, technological improvements compatible with sustainable ecological development or ecological innovations that are also created in one of the following or other related fields of science, for example: Molecular Biology, Biotechnology, Anthropology Theory, Medicine, Electrical Engineering , Artificial Intelligence, Genetics, Business Administration, Risk Management, Big Data, Business Intelligence, Automation & Robotics, Climatology, Agriculture, Biophysics, Biochemistry, Medical Intelligence, Artificial Neural Networks, Ecosystem Analysis, Power Engineering, Construction, Food production, Forest ecology, Biology, Geoscience, Government Programs, Behavioral Sciences, Biodiversity Assessment, Green Architecture, Greenhouse, Waste, Household 顺心彩票, Information Society, Innovation Management, International Entrepreneurship, Internet Technologies, Knowledge Creation, Bioelectric Energy gy Sources, Business Model Innovation, Cataclysmic Variables, Chromatography, Clean Energy, Cleantech, Climate Prediction, Collaborative Innovation, Commercialization, Computational Intelligence, Computer Science and Engineering, Conservation Biology, Consumer Behavior, Corporate Governance, Creative Economy, Crisis Communication, Cyber ??Security, Data Analysis, Database Administration, Development Cooperation, Digital Ecosystems, Discovery, Earth Sciences, Earthquake Forecasting and Geocataclysm, Econometric Analysis, Economic Integration, Economics of Innovation, Ecosystem Engineering, Electricity, Electronic Systems, Energetic Materials, Energy Technologies, Environment, Environmental Biodegradation, Flora, Food Consumption Life Sciences, Logistics Management, Materials for Sustainable Energy, Astronomy & Astrophysics, Nanomaterials, New Media Technology, Recycling, Physics of Global Warming, Plant Protection, Predictive Analytics, Production Planning, Project Development, Public Eco nomics, Public Policy, Public Policy, Sociobiology, Space Science, Sustainable Agriculture, Sustainable Development Strategies, Technology Forecasting, Transport Economics, Water Resources, Weather Forecasting, Wildlife Conservation, World Economy, ...?
In view of the above, the current question is: Will ecological innovations be created in the 21st century on the basis of other sciences besides ecology?
Please, answer, comments. I invite you to the discussion.
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Ecological inventions are need of the world to prevent destruction of the earth. Therefore we can hope more and more eco-friendly inventions will appear in 21st century.
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According to the local journals in my country the maximum number of researcher that can subscribe in a specific research is Three. If there is an additional researcher/s, then he/they will not get any benefit from the research.
Please reply, and share us your opinions about the discussion .
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Dear Dr. Mohammed,
There are no limits to the number. But the number of researchers must be logical and each one has a clear role.
Regards.
Rama
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Hello,
what do you think about gut microbiota and its role in obesity ?
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This is an interesting article for your question
Adv Nutr. 2016 Nov 15;7(6):1080-1089. doi: 10.3945/an.116.012914. Print 2016 Nov.
Gut Microbiota in Obesity and Undernutrition.
de Clercq NC1, Groen AK2,3, Romijn JA2, Nieuwdorp M2,4,5.
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What is the difference between a medicine and drug?
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Medicine is a substance or preparation used in treating disease, while drug is any chemical compound either synthesized in laboratory or of plant, animal or marine origin which is intended to bring change in normal physiological functions of body. All medicines are drugs but all drugs are not medicines.
Medicines generally are not addictive in nature, unlike drugs. Medicines are made for the treatment of a particular disease, while drug is often considered as narcotic, a stimulant or hallucinogen. Medicines never cause stupefaction while drugs do. However, excessive use of medicines are harmful and can cause negative affects like drugs.
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Apparently, untreated tooth decay can be the source of the appearance and development of various diseases and other diseases in the human body.
Therefore, the current question is: Can dental caries cause other serious diseases?
Please, answer, comments. I invite you to the discussion.
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Yes, the most important bacterial spread in the blood and recorded cases of atherosclerosis and high risk of CVS problems and the most serious cases registered for patients with diabetes
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Hi, I am looking for a software for detection (diagnosis ) of moulds in the laboratory specially the (medical important fungi) depending on macroscopic and microscopic feature of isolated fungi, any suggestion or help will be appreciated.
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Hi everyone,
I am a master student in medicine.
in the paper " Late Ca2+ Sparks and Ripples During the Systolic Ca2+ Transient in Heart Muscle Cells", I dont understand how to measure the distance from T-tubule to Late calcium spark (figure 1D). is there anyone can explain more detail about the figure 2D in this article for me please?
Thank you for taking time resolving my issues.
and this is the context:
" A simple, obvious, explanation for the genesis of the LCSs would be that they arise from jSR that was either not activated during the upstroke of the Ca2+ transient or was uncoupled or orphaned17 from t-tubules (which carry the AP to the cell interior). To examine this idea, we labeled t-tubules (Figure 1D) and measured the Euclidian distance to the LCS centroid (Figure 1E) and compared the latencies for the upstroke of the Ca2+ transient at LCS sites to overall Ca2+ transient latency (Figure 1F). Perhaps unexpectedly, LCS occurred close to t-tubules and at positions where the Ca2+ transient developed with a shorter than average latency (P<0.05). This suggests that LCS usually arise from sites that are not orphaned but are, in fact, well coupled, a view also supported by the presence of an extensive ttubule network (top and middle panels, Figure 1D) that did not show any signs of the disruption associated with orphaning. "
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and in this paper, we dont know which cell-patch clamp technique the authors used, they only said that the whole-cell patch was not used to avoid dialysis.
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What should researchers do to attract more citations? How do external and internal collaborations impact citations?
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Always buildings are damage by an Earthquake. So we have prevent to lose the people poverty, How?
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I recommended the following presentation
Best Regards Javan Doloei
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Hello,
to my knowledge Au Nanospheres used are hollow to exploit medical usage i.e. medicine loading, imaging etc. and lower the amount of Au in vivo. In what instances, if at all, are solid Au Nanospheres used instead and why?
Much Thanks:)
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My understanding is that hollow NPs are preferred exploiting less in vivo toxicity, imaging, drug carrying techniques etc. but just not always thermodynamically possible and therefore then solid. (However there may be instances were all solid is preferred i.e. gathering more heat to the NP that I am just not savvy to, feel free to add :) .)
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In our lab we are measuring serum Na concentrations using a Medica Easylyte device. We prefer to use fresh sample to do our readings and when we do they generally come out fine. However, when we have to freeze the sample we run into issues. Once the samples are thawed the serum NA concentrations are much lower then in fresh sample and continue to drop with additional readings. The samples are stored at -80 degrees Celsius in Fisher brand microcentrifuge tubes (02-682-556). Does anyone have any idea what is happening?
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How much of a difference are you seeing? I have tested samples after freezing with no significant issues for electrolytes just to see. There were slight variations, but these were minimal.
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Three months earlier i was diagnosed with extra-pulmonary tuberculous empyema and i lost about 6 KG.after using anti tuberculous medicine for 3 moths i gain 5-6 kg of weight. but may x-ray does not show any improvement. Does it means i am improving?
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In medicine, observing changes in initial symptoms& signs during treatment course does reflect response to treatment. Weight gain accompanying anti-TB drugs administration mostly indicates the ongoing cure.
Best wishes for better health
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Hi. Do we need to ask permission from the related publishers if we want to use tables and figures from journal article or a citation is enough ?
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Since the copyright of an article has to be transferred to the publisher by the author(s) before publication, permission to use a table or a figure has to be requested from the publisher. It must be cited in the legend of the table or figure with reference and "with permission of ...". There is an exception only with public sources, whereby the source must be specified however also exactly.
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#patent #generic #difference #costeffect #effetiveness
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The drug which is protected by patent is a branded drug (Patent Medicine) and the drug which is a copy of branded drug and is equivalent in terms of safety, efficacy, dosage and use is called a generic drug. Generic drugs will cost less.
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With genetic modification in the news, it seems the time has come to openly discuss the possibilities (for better or worse) of human gene editing.
Ethical and moral dilemmas aside, if it has actually been done and there exist modified humans circulating in the population, what is the future of the human race?
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Hi there,
Good point you raise here! I raised it in my class a few days back.
From an ethical point of view, I have my serious hang ups because this door may lead to all sorts of things. My other concern is that we may be tampering with the natural order of things, whose full impact and implications into the future is unclear. Third, some one is trying to play "creator" and that should be left to God or nature alone.
On the positive side, Gene editing may help in many ways, provided it is seriously and ethically regulated. The trouble is that in a post modern context, it is very hard to arrive at consensus on what is right or wrong. A good frame work would limit or prevent abuse, encourage decision by the parents or patients etc. It may further help us avert some terminal illnesses that have menaced the world thus far.
If you asked me, I would rather travel circumspectly on this path. Let nature be nature.
Cheers
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In the course of discussions of the question: ?A funny question: bacteria in the brain; do they migrate thereto or originate therein?? at the RG pages (http://www.fondpageant.com/post/A_funny_question_bacteria_in_the_brain_do_they_migrate_thereto_or_originate_therein ), it was first noted that, when considering the causes of the appearance of the microorganisms in brain, the possibility of their formation within the brain cells should not be excluded. The logic of this sentence was as follows. Because the formation of new neurons and, consequently, new DNAs in the brain cells is, at present, a well-known fact, free nucleotides and nucleosides occur within cells; therewith, side processes of formation of rather short foreign DNA-like molecules and their subsequent replication, seemingly, cannot be completely excluded. Such a sentence doesn't contradict the context of the Mitosis and Replication Hydrate Theory (MRH-Theory) developed by us.
If similar processes are really inherent in Nature, they would be of great importance for the general biology, medicine, and species diversity history.
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i agree with Victor Ostrovskii
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Indeed, I have observed that there is some scientific journals that listed in Scopus sources of not good quality from scientific point of view. At the same time some Universities are depending on Scoups in a similar manner to that of Thomson & Routers or Clarivate analytics.
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Depends on your country/ university rules. In Croatia it is.
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In a patient with hereditary desminopathy (mutation Thr341Pro DES in the heterozygous state) over the past three years, an increase in the blood uric acid level up to 440-480 μmol / l was established by 1.5 times (the norm is 428.4 μmol / l). With the progression of the disease, the level has risen and is above normal. It is known that uric acid is an antioxidant. Is it necessary to reduce the level of uric acid? The patient has no problems with the joints.
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Dear Boris Schmitz and Igor Popov, thank you very much for your answers. The level of ascorbic acid in the blood of a patient with desminopathy within two years is in the range of 4.7 - 6.2 μg / ml (the norm is 4-20 μg / ml).
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Your ability to lose, gain or maintain your weight is dependent on genetic, environmental, and behavioral factors. But how much of a role does genetics play in weight loss versus eating a healthy diet? Is there any truth to genetics playing a substantial role in your ability to lose weight to improve health and overall body composition? Or the exercise and diet is the driving factor?
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I have diabetes because my mother was also diabetic. However; I am fine only with low carb diet and no medecine at all. It is not easy ; especially in the beguining. However diet not only solved my diabetes problem but also made my immunity system stronger. I feel much healtier now than when I had diabetes fifteen years ago.
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This is a rapidly evolving world with many new biotechnologies entering & some being scapegoated to allow the new ones to be accommodated.
Do you meicinecwith its enormously spreading domain may face extinction to allow new specilities,like molecular medicine
Regards
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As the time passes, the new innovations, new technology and new concepts are coming forward. It's the natural that the changes will occur.
New researchers and scientists have discovered many techniques/technology for the welfare of mankind. It's but natural that the medical science evolving at very fast pace with new developments and old ones are like second fiddle. Changes are must for good.
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The expiry date written on the medicine does the expiry of the medicine mean that date or before or what?
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The manufacturer of drugs gives the expiry date till which he guarantees the potency of the drug. He does not say that the drug is not to be used after the date of expiry. It is up to the consumer if he wishes to use it or not. This is the legal position.
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In the Western world, many of the lectures for medical students and trainee doctors are conducted online. Are we excluding certain important aspects of face to face medical education by adhering to this? What is the appropriate balance between face to face and online training?
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I do not see how clinical teaching (as I understand the term)?could be effectively done online, with the possible exception of learning to read imaging studies (which are more and more being read by machines in any event).? "Clinical teaching" is meant to have the student learn how to observe and interact in a physical way with a patient, in order to come to some conclusion about the patient's condition and potential treatment.? This involves physical interaction through touch (e.g., palpation, clamminess, patient's reaction to motion or touch), sound (e.g., interpreting the sounds from a stethoscope placed at the correct locations, patient's verbal cues),?sight (e.g., capillary refill, pallor, patient's body language), and more.? Teaching a student *might* eventually be done (likely at great expense and with efficacy yet to be proven) with simulators (that are not yet developed to the level needed to develop our future physician's skills to the level I'd want *my* doctor to have!? ;).?
Even assuming on-line interaction at places with advanced simulators, that still leaves the problem of evaluation of the student's development of the needed clinical skills.? This?involves very close observation of the student by the teacher to be able to assess "soft skills" such as effective communication and empathy.? In theory, multiple cameras could observe an interaction (as in current day OSCEs) and a teacher could assess the session asynchronously, but it still comes down to one teacher per student event in something that probably cannot be adequately automated.?
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Can Metformin use as a medicine for breast cancer?
What are the advantages and disadvantages of using Metformin in patients with breast cancer?
Is it possible to use Metformin for both diabetes mellitus and breast cancer?
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There is no known medication or therapeutic technique that is able to completely prevent malignancies, oral or otherwise. Anyone who claims that metformin completely prevents Breast cancer is either a misinformed medical lay person, or a quack practitioner.
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Science and technology are complementary to each other. The ancient humans developed technologies to survive in earth through different raw materials and tools. They didn't understand the science behind those things. No research was conducted. Everything was generated by trial and error method. Even the animals also go on the same path. I am seeking a constructive discussion regarding arrival of science and technology in human civilization. Which came first?
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Science exists since the day on which universe was created. We may have found the answers to many questions related to science later. But it does not mean that it was not there before. In 1687, Newton presented his theory of universal gravitation and three laws of motion. Does it mean that law of gravity didn't exist before it was demonstrated by Newton?
Science is investigated but technology is created. In the words of Albert Einstein, “Scientists investigate that which already is; engineers create that which has never been.”
Everything can be explained by science. We have not created science, it was there before us and before everything. As per Collins English dictionary, "Technology refers to methods, systems, and devices which are the result of scientific knowledge being used for practical purposes".
So, application of science to develop new devices, systems or methods is called technology.
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Researches claimed that this blood is more efficient for medical use than blood collected from donors. Patients with rare blood types will benefit the most.
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The term "Artificial blood" is a misnomers and can't be prepared in laboratory. There is a limitation of stem cells culture in vitro and component in whole blood is much more complex.
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I am pleased to announce the special issue called "Autonomous Health Monitoring and Assistance Systems using IoT" in three participating journals of #Frontiers, namely Robotics and AI (Sensor Fusion and Machine Perception), Big Data (Medicine and Public Health), and Artificial Intelligence (Medicine and Public Health). Click here for more details: https://www.frontiersin.org/research-topics/9073/autonomous-health-monitoring-and-assistance-systems-using-iot?fbclid=IwAR3wnRUldrHaI4r3fqc5QpuAeBFI-sydsRCCXecZP_T2e6q1wtTFfUtwfss
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In the field of public health research is always needed, supported and interested in co-operation.
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Researchers in the field of chemistry, biomedical engineering and medicine invited to co-operate in high-tech research team in related fields. Researchers who are interested, send me a message.
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May I know, are we going to explore bioactive compounds in phytoconstituents or synthetic molecules? My research group is presently working on angiosperms and pteridophytes as source(s) antimicrobial and bioactive molecules.
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Ifosfamide is one of the most famous and useful drugs for cancer but its very important that you know this pharmaceutical compound has many harmful effects on sick people , one of which is bleeding that is very danger for them and it might be so unbearable .
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Also, keep in mind that treatment with Ifosfamide results in myelosuppression - the low platelet count could be a factor. Hemorrhagic cystitis can often be successfully prevented by administering mesna.
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I was wondering if the dialysis system has some sort of sensor to detect the right fluid inserted.
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Surely the new technologies for the treatment of water for dialysis and the sterility of the system have drastically reduced the episodes of fever on dialysis. The use of the jugular vein for the insertion of central venous catheters, the use of tunneled catheters and the nursing techniques of aseptic line connection contributed to the drastic decrease of sepsis .Each dialysis center pursues its own strategy with ad hoc protocols. The use of high-or low-concentration citrate for the final filling of central venous catheters. The use of chlorhexidine instead of Betadine for the disinfection of the skin also for the insertion of the fistula needles. All strategies that require lengthy discussions, but above all a widespread conviction of the staff all: doctors and nurses.
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Many people use lenses in order to experience different eye color & also instead of glasses and etc.
It is important to bring lenses out of the eye ,daily otherwise side effects happen like dry eye disease.
So these lenses can be useful.
Is it possible?
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For therapeutic purpose, why not?
Same principle as biodegradable materials.
Site and desgin: as that of the ICL (different material and different purpose)
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Please make your valuable comments regarding the above discussion.
Society science engineering biology genetics artificial intelligence life science evolution sociology psychology behavior medicine biotechnology warfare population earth civilization
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The world has currently reached the peak of its development in all fields. However, there is a growing fear of the risks that war between the super powers may erupt if so extreme or irrational people assume power and take decisions that may lead to the destruction of human civilization. Despite all this fear, we look forward to the prevailing of stability and peace all over the world.
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If so, is there any evidence for that?
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One has to make certain one has baseline liver enzymes prior to any exposure to aspirin then another set of enzymes post-exposure to aspirin.
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I know that an infant's brain can repair itself when damaged but why doesn't the same happen in adults after stroke or brain injuries?
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The infant brain has better plasticity than the adult brains. The regeneration of brain and vessel in the damaged region occurs in both infants and adults, which means the brain can also regrow in adult to some extend. However, the ability of regeneration seems to be higher in infants. Additionally, infant brain has more "clean space" to establish the neuronal circuit for functional restoration.
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Since I'm working on inject medicine to dorsal raphe in mouse by stereotaxic apparatus, even though I can check out position coordinate in reference <the mouse brain>, it is better to recheck whether the position I injected is correct before the formal experiment. Is there any way to find out the correct position of dorsal raphe? Like marker or landmark nearby?
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One guide would be to use the recording electrode and look for a distinctive pattern of DRN activity..
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Innovative new types of materials, new types of substitutes of existing raw materials that have been used in various branches of industry have often been created in laboratories of research centers, research centers of technology companies operating in the biotechnology sector, construction engineering, space exploration programs, etc.
In the 21st century, new material innovations will have to be created for the purpose of creating ecological substitutes for the exhausting traditional minerals of energy raw materials.
In addition, further material innovations will have to be created for the creation of ecological, biodegradable substitutes for hard-degradable plastic packaging, dishes and fast-moving products.
Material innovations are currently being created for the needs of construction, environmental protection, ecological energy, medicine, etc.
Will the observed trends in this field change over the next several decades?
Are material innovations mainly created as a result of deliberately planned research projects carried out in specialized research laboratories?
However, are they more often created accidentally in research projects, the aim of which was to explore a completely different issue, to create a technical invention or a completely different branch of innovation?
In addition, the question is also current: In what branches of industry will the most material innovations in the 21st century be created?
Please, answer, comments. I invite you to the discussion.
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Nanotechnology, it'll strongly and revolutionary change everything in the 21'th century, but in phases.
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Dear RG members,
The term ‘human nature’ is much more than a reference to human behaviour; it actually refers to our species’ less-than-ideally-behaved, seemingly-imperfect, even ‘good and evil’-afflicted, so-called human condition—as in ‘it’s only human nature for people to be competitive, selfish and aggressive’.
Here we all are constantly searching for new thing that is unknown. There is only one flaw which can be seen as a continuous flow : "I am human and I can do anything what I want or like"
So, I would like to know how your research is going to help others or it is just useless after thesis binding?
Regards
Pankaj
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Dear Pankaj,
"How your research is going to help others?" -- you ask
In a humble way I think that my reseacr is going to help others. When I perform research, my idea is to get a better knowledge of the unknow. So, this better knowledge of the unknow can be, for example, a source of inspiration for others to continue to explore my ideas in further research and/or to apply them in the practical domain. In addition to being a source of inspiration for younger reseachers, my research may help others in the sense that what I had done does not need to be done anymore.
Kind regards.
Orlando.
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Is it essential to have 'medical grade' CO2 gas for our CO2 incubator, or will any standard tank of CO2 from a local supplier work fine?
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There are many methods for a drug to be used, such as oral methods (pills), anal methods, injections, etc. But when a new drug invented, how do scientists choose the best way to insert it into the body? how they decide to convert the drug to pills or injections or any other types?
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There are a variety of reasons that a given drug administration route is taken, among which are:
  • Physical and chemical properties of the drug. The physical properties being solid, liquid, and gas. The chemical properties primarily being solubility, stability, pH, irritancy, etc.
  • Site of desired action: the action may be localised and approachable or generalised and not approachable.
  • Rate of extent of absorption of the drug from different routes.
  • Effect of digestive juices and the first phase of metabolism.
  • Condition of the patient.
There are other factors too--often a drug can be given in multiple forms, and then it can come down to cost or patient comfort (for example, someone may prefer a daily pill to going in for an injection daily). The other factor in how a drug is commercialized is the form in which it was tested in animals. You will have a harder time getting a pill approved if all your in vivo tests are with tail vein injections, for example. But if your in vivo experiments involved an ingested oral dose, getting a pill approved is easier.
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There are a variety of peptides that have numerous outstanding benefits for human health. From my small time understanding the properties of medicinal peptides I have discovered many that target the most dangerous of diseases that human race has a offer. Most boast benefits beyond typical antibiotics due to their tendency to eliminate deadly diseases by damaging the cell in numerous ways-- some by allowing organelles and RNA to escape (MP-1) or by targeting the cell nucleus (VLL-28). Synthetic biology in the distant future may be the future of medicine, but producing cheap liposomes and innovating procedures humanity could reap the benefits of the many opportunities available by peptide medicine. I have found numerous other peptides that target HIV-1, for example. What are your thoughts on liposomal medicine? Do you as professionals believe that the human race will find unequal benefit from the medicines that can be created?
Thank you!
-Tyler
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I am anxiously awaiting these results.
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James P. Allison and Tasuko Honjo were announced to receive the Nobel prize. I remember the big talk by James Allison - and more or less a whole conference last year in London. There are, as usual, many contributors to the field, and my impression over the decades was, that Nobel prizes are often decades after the findings. Is this a relatively fast Nobel recognition?
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Cancer is one of greatest health problems, second leading cause of death globally, and is responsible for an estimated 9.6 million deaths in 2018. The Nobel Prize in Physiology or Medicine 2018 was awarded jointly to James P. Allison and Tasuku Honjo "for their discovery of cancer therapy by inhibition of negative immune regulation." Congratulations!
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Does anyone have innovative engagement or recruitment strategies for hard to reach populations?
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There are no easy answers to this in my experience with refugee communities.
I worked with a local clinic who have been there for nearly 10 years. The women I work with respect the clinic's incredible input into their community, and, as a result, are motivated to be part of their research projects.
One thing to note is that there is an increasing tendency to refer to these kinds of communities as 'less-often heard' instead of 'hard to reach'.
Good luck with your work!
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What is the Best resource/Website to learn the pathology of any disease?
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You should consider to have a look at :
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Artificial Intelligence is starting invasion in different medical subspecialty
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Perhaps one of the most interesting applications is in the design of "dynamic biomarkers". That is to say, biomarkers whose meaning is extracted from its variation and relations of variation at certain moments instead of its absolute value.
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What do clinician-researchers think of manualized peer support? What do peers/patients think of manualized peer support?
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Well clinician-researchers, if they believe in what they have manualized and have evidence (or are building evidence) on efficacy probably find these approaches help make research more manageable and the assurance of quality in delivery more possible and measurable. For peers, some welcome the structure and like the reassurance of an "approach". Others feel they know better about the issue,... and maybe they do,... and feel restricted by the manual. .. and some also warm up the manual over time.
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I see that there is a great discussion about the real efficacy of medical treatments in the conventional medicine. I've read about of Grade A guideline treatments that only find 20% succsessful healing. Can you support this number? And if yes, dou you have references?
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At the moment I can give you just an empirical answer. I suspect that in the discussion we are talking about two kinds of matter. In any case as a practioner, if there is a evidence based gudeline I use it but this is not always the case. The numbers you give seems to me not realistical. My realistic empirical espectations for a satisfactory effect of first choice treatment are : antidepressants 50- 60 per cent; antipsychotics 60- 65 per cents; antibiotics ( after aimed choice ) 80 per cent; antipertensive 70 per cents; ansiolitics ( short period ) 80 per cent. This is my medical common sense empirical answer, and about just some example of treatment.
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Compared to extremely unhealthy recommendations by English doctors in Shakespeare's time (discouraging baths, blood-letting), Ancient Egyptians had an extremely sophisticated understanding of the cardiovascular system, surgery and appropriate herbal medicines still in use and effective today. Why were European doctors so far behind African advancements in medicine?
Ancient African Women's Rights and Lifestyle:
Until recent Suffrage Laws, modern women in American and European cultures had very few rights compared to women in Africa during Europe's Dark Ages. Why is it taking several centuries for Europeans and Americans to accomplish what Africans accomplished thousands of years ago?
The respect accorded to women in ancient Egypt is evident in almost every aspect of the civilization from the religious beliefs to social customs. The gods were both male and female, and each had their own equally important areas of expertise. Women could marry who they wanted and divorce those who no longer suited them, could hold what jobs they liked - within limits - and travel at their whim.
Why is it that European and American scientists still do not know how ancient Africans built the Giza Pyramid?:
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On the East coast there was certainly urban development although Zimbabwe, an important city, was not built until about the 14th century. But in truth, archaeology is lacking for many parts of sub-Saharan Africa as nobody has expected or expects anything. Mali of course was then a rich and influential state. Famously, the Moors arrived in Spain from Morocco and other parts of Northern Africa and built one of the outstanding civilisations of the time.
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The patient who was 63 years old was hospitalized with a pulse rate of 35 bpm with irregular heart rhythm on ECG and had breathing difficulty with severe fatigue. She was diagnosed with a third degree atrioventricular block and sick sinus syndrome (bradycardia).
However, with the correct course of medication her heart rate increased to 45 from 35 bpm within a week with anti-arrhythmic drugs. Now she is much better with very little fatigue.
Is there a chance for her to recover completely without a pacemaker?
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Sick sinus syndrome and third degree atrio ventricular block are the most important causes for bradycardia. Sick sinus syndrome predominantly involves the sinus node but often is associated with varying degrees of involvement of the atrioventricular node and rest of the conduction system. A variety of reversible, transient factors can lead to AV block and bradyarrhythmia. This include Digoxin, Ivabradine, some drugs used for management of hypertension like beta blockers and calcium channel blockers like Verapamil and Diltiazem. Many anti arrhythmics like Amiodarone can also produce slowing of heart rate.
Hypothyroidism, electrolyte abnormalities like hypokalemia and hypothermia are other factors. Certain poisons and toxins like odollum and oleander can also produce Brady arrhythmias.Certain neurological conditions and many viral fevers can produce temporary slowing of heart rate.
Inferior wall myocardial infarction can produce bradycardia and fatigue in elderly sometimes without chest pain.
Even without any apparent reason, the heart rate tend to be variable in some patients with sick sinus syndrome.Heart rate may be fairly normal on certain occasions even in symptomatic patients.