Questions related to Medicine
- Apr 30, 2020
Some people claim that the people that need the vaccine the most are the least able to pay for the vaccine. Is this a correct claim? If yes, what should be the appropriate policy response?
Joseph Tham how are you? i would like to answer that yes, but the role of this COVID 10 pandemia during the last 4 months showed that not, underline because according with the human kind`s history: health, education, and human peace progress never being something really important for political leaders in opposite way the budget for supporting war in all sense always being the main aim of the rich countries developing or even poor countries.
- Apr 29, 2020
- Apr 27, 2020
As a public health measures to control the spread of the pandemic coronavirus, social distancing and 顺心彩票 quarantine are implemented in some countries.
As a matter of fact, patients are absence from clinic under COVID-19, and clinic-based diabetic control monitoring becomes challenging.
Do you expect a change in diabetic control for these patients when staying 顺心彩票?
They have less exercise, and may eat more snacks at 顺心彩票.
Or in contrast, they are too bored, and have time to develop new exercise without pressure from work? Besides, they are banned from social around, and may eat drink less alcohol and eat less feast.
What do you think?
COVID-19 will increase vascular complications
Coronavirus associated with respiratory distress and ph changes Both Quarantine &Thinking increase stress hormones so more oxidations Limited Exercise will increase blood glucose level
Presentation Patient Treatment in Corona Virus
- Apr 24, 2020
What are the latest updates about the route of transmission and its impact?
Dear Dr. Ebada,
We know very little about COVID-19 at this moment and its effects on the developing and/or mature brain. In general viral infections can impair charnolophagy (CB autophagy) which is the basic molecular mechanism of intra-cellular detoxification (ICD) for normal function to remain healthy. By attacking the most sensitive neural progenitor cells in the brain, the virus can alter their pluripotency and induce charnolosome (CS) destabilization implicated in inflammasome (particularly NRLP-3) activation to induce hypercytokinemia and charnoptosis (CB apoptosis) implicated in pyroptosis, apoptosis, and necrosis of sensitive hippocampal and other CNS neurons by releasing Panx-1, Viroporine, and gasdermins to cause Charnoly Body Molecular Pathogenesis (CBMP) implicated in early morbidity and mortality through its general (Viral) lytic cycle.
For more details, you may please refer to my books " The Zika Virus Disease: Prevention and Cure" The Charnoly Body: A Novel Biomarker of Mitochondrial Bioenergetics" Fetal Alcohol Spectrum Disorder; and Nicotinism and Emerging Role of E-Cigarettes. I wish I could write more about it.
Dr. Ebada, It is all about Environmental Sanitation, our own Life-Style, Immunity, Mitochondrial Bio-energetics and intracellular detoxification through charnolophagy (CB autophagy), which is compromised by COVID-19 through CS destabilization to cause early morbidity and mortality by infecting the CNS. Thanks.
With Warm regards,
Sushil Sharma, Ph.D; D.M.R.I.T
American International School of Medicine
Guyana, South America
- Dec 14, 2019
The image shows surgical and gynaecological instruments used by ancient Egyptians over 3000-5000 years BC. It explains how advanced medicine at that time, scalpels, forceps, curettes were known and what we use as surgical instruments date back to ancient Egyptians designs. The question is, do you have a history of medicine in your medical/health curricula? What are the objectives of this component? And how do you integrate this part to other elements in the curriculum?
I agree with the answer of Dr. Om Prakash Sudrania .
- Jan 29, 2020
A milestone by Theodor Billroth in surgery and cancer surgery.
- the 139th anniversary day (Jan 29, 1881)
Christian Albert Theodor Billroth (1829-1894)
the first successful distal gastrectomy
for gastric cancer within 90 min
However, we may should be aware that everything in medicine surgery cancersurgery science needs teamwork
We are nothing without the Team!
Theodor Billroth *26 Apr 1829 ?06 Feb 1894
Remembering giants in science, medicine and surgery - German Surgeon & Co-Founder of academic surgery
"I can not understand how someone can read receptively only"
"Only those who know the past & present of science and art, will boost their progress with awareness"
~ Theodor Billroth
- Apr 26, 2020
COVID-19 is spreading around the world, and faeces were popular and agreed for the presence of viral RNA with different studies reported. Its presence mean that the gastrointestinal (GI) tract is one of the hosting organ for such coronavirus.
How are other parts of the GI tract system affected by this virus?
Clinical features of covid-19-related liver damage.
Clin Gastroenterol Hepatol. 2020 Apr 10.
Pancreatic injury patterns in patients with COVID-19 pneumonia.
Gastroenterology. 2020 Apr 01.
Please see the following RG links.
- Apr 6, 2020
Under COVID_19, most evidence and data are on adults, but more and more paediatric cases with some mortality are ongoing.
Let's gather all the paediatric related COVID-19 research here for referencing.
1) Yung CF, Kam K, Wong MS, et al. Environment and Personal Protective Equipment Tests for SARS-CoV-2 in the Isolation Room of an Infant With Infection. Ann Intern Med. 2020; [Epub ahead of print 1 April 2020]. doi: https://doi.org/10.7326/M20-0942
2) Brooks Samantha K, Smith Louise E, Webster Rebecca K, Weston Dale, Woodland Lisa, Hall Ian, Rubin G James. The impact of unplanned school closure on children’s social contact: rapid evidence review. Euro Surveill. 2020;25(13):pii=2000188. https://doi.org/10.2807/1560-7917.ES.2020.25.13.2000188
3) Dong L, Tian J, He S, et al. Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn. JAMA. Published online March 26, 2020. doi:10.1001/jama.2020.4621
4) Iqbal SN, Overcash R, Mokhtari N, Saeed H, Gold S, Auguste T, et al. An Uncomplicated Delivery in a Patient with Covid-19 in the United States. N Engl J Med. 2020 Apr 01.
5) Qiu H, Wu J, Hong L, Luo Y, Song Q, Chen D. Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study. Lancet Infect Dis. 2020 Mar 25.
6) Zeng H, Xu C, Fan J, et al. Antibodies in Infants Born to Mothers With COVID-19 Pneumonia. JAMA. Published online March 26, 2020. doi:10.1001/jama.2020.4861
7) Zeng L, Xia S, Yuan W, et al. Neonatal Early-Onset Infection With SARS-CoV-2 in 33 Neonates Born to Mothers With COVID-19 in Wuhan, China. JAMA Pediatr. Published online March 26, 2020. doi:10.1001/jamapediatrics.2020.0878
8) Chen D, Yang H, Cao Y, Cheng W, Duan T, Fan C, et al. Expert consensus for managing pregnant women and neonates born to mothers with suspected or confirmed novel coronavirus (COVID-19) infection. Int J Gynaecol Obstet. 2020 Mar 20.
Article COVID-19 Infections in Newborns
- Apr 24, 2020
I am interested in collaborating with any researcher working on modelling corona virus using fractional derivatives. If you are a researcher or you have a related project, please feel free to let me know if you need someone to collaborate with you on this research study. If you know someone else working on this research project, please share my collaboration interest with him.her. I would be very happy to collaborate on this research project with other researchers worldwide.
Yes, I am working on such modelling for the COVID-19, and I am ready to cooperate with you in this hot topic.
- Apr 16, 2020
COVID-19 is in no doubt affecting every walks of life. Its impact towards every one and others' psychological and psychiatric health is significant, yet how should we quantify them?
Let's pull all related publications here for reference:
Understanding and Addressing Sources of Anxiety Among Health Care Professionals During the COVID-19 Pandemic
The Mental Health Consequences of COVID-19 and Physical DistancingThe Need for Prevention and Early Intervention
Please take a look at the following RG links.
- Apr 21, 2020
In my circle of friends there is a lively debate if corona is as dangerous as our media and governments is trying to portrait. Im one of those who doesn't believe Covid 19 is so much more dangerous to the general population than, lets say the flu. With that said I dont mean I would like to contract it, or any other illness. What is your take on the current situation? Is Covid 19 in your view something to be feared or do you like me view it as something that should not affect our lives and our economy to the extent it now has. How does your society handle the issue and what is your take? Best regards Henrik
Novel coronavirus (SARS-CoV-2) is less fatal than SARS coronavirus (SARS-CoV) and MERS coronavirus (MERS-CoV) but it is highly contagious.
- Apr 15, 2020
Respiratory infections can be transmitted through droplets of different sizes: when the droplet particles are >5-10 μm in diameter they are referred to as respiratory droplets, and when then are <5μm in diameter, they are referred to as droplet nuclei. According to current evidence, COVID-19 virus is primarily transmitted between people through respiratory droplets and contact routes.2-7 In an analysis of 75,465 COVID-19 cases in China, airborne transmission was not reported.
Droplet transmission occurs when a person is in in close contact (within 1 m) with someone who has respiratory symptoms (e.g., coughing or sneezing) and is therefore at risk of having his/her mucosae (mouth and nose) or conjunctiva (eyes) exposed to potentially infective respiratory droplets. Transmission may also occur through fomites in the immediate environment around the infected person. Therefore, transmission of the COVID-19 virus can occur by direct contact with infected people and indirect contact with surfaces in the immediate environment or with objects used on the infected person (e.g., stethoscope or thermometer).?
Airborne transmission is different from droplet transmission as it refers to the presence of microbes within droplet nuclei, which are generally considered to be particles <5μm in diameter, can remain in the air for long periods of time and be transmitted to others over distances greater than 1 m.?
In the context of COVID-19, airborne transmission may be possible in specific circumstances and settings in which procedures or support treatments that generate aerosols are performed; i.e., endotracheal intubation, bronchoscopy, open suctioning, administration of nebulized treatment, manual ventilation before intubation, turning the patient to the prone position, disconnecting the patient from the ventilator, non-invasive positive-pressure ventilation, tracheostomy, and cardiopulmonary resuscitation.?
There is some evidence that COVID-19 infection may lead to intestinal infection and be present in faeces. However, to date only one study has cultured the COVID-19 virus from a single stool specimen.? There have been no reports of faecal?oral transmission of the COVID-19 virus to date.
Please see the link below.
- Apr 6, 2020
Probiotics are live microorganisms that are intended to have health benefits when consumed or applied to the body. They can be found in yogurt and other fermented foods, dietary supplements, and beauty products.
Please take a look at this useful link.
- Apr 4, 2020
Under COVID-19, many human activities are suspended, public entertainment places are closed down. Football legends are almost fully cut off worldwide.
The targets for gambler to bet are less and less, no matter football, horse racing, boxing, bar ...
How do the psychiatric addictive gambler coping with their addiction under COVID-19?
In psychiatry, psycho therapy or behavioral modification is always used. Is COVID-19 helping these addictive gambler to run out of their obsession?
In Hong Kong, currently popular legal physical (non-online) gambling would be horse-racing football and mark-six (a kind of lucky draw for numbers). Of course, there are many more different ones online.
However, the responsible organization (Hong Kong Jockey Club) closed down all the branches since COVID-19. There is a short period in between that it was re-opened, and many gamblers grasped the time to go in to refill or retrieval their accounts' money.
Unluckily, under social distancing rule, race course is banned for entry even for horse owners.
As a citizen, I can feel how broken hearts these horse racing gamblers are. And with time of few months, I feel that horse racing is falling out of colour.
Besides, football legends all over the world is closing as well. And bars for alcohol are all closed down by law too.
Of course, there is also Majong. Yet, shops providing these are also closed.
That's why I feel that people may shift their attention to others under COVID-19.
- Apr 20, 2020
The virus is primarily spread between people during close contact, often via small droplets produced by coughing, sneezing, or talking. While these droplets are produced when breathing out, they usually fall to the ground or onto surfaces rather than remain in the air over long distances.People may also become infected by touching a contaminated surface and then touching their eyes, nose, or mouth. The virus can survive on surfaces for up to 72 hours. It is most contagious during the first three days after the onset of symptoms, although spread may be possible before symptoms appear and in later stages of the disease.
- Apr 4, 2020
Dengue fever is a disease caused by a family of viruses transmitted by infected mosquitoes. It is an acute illness of sudden onset that usually follows a benign course with symptoms such as headache, fever, exhaustion, severe muscle and joint pain, swollen lymph nodes (lymphadenopathy), and rash.
Please go through the following RG links.
- Apr 20, 2020
A hospital-acquired infection (HAI), also known as a nosocomial infection, is an infection that is acquired in a hospital or other health care facility. To emphasize both hospital and nonhospital settings, it is sometimes instead called a health care–associated infection (HAI or HCAI).
Please see the following RG link.
- Apr 11, 2020
COVID-19 is putting a huge impact on the society by the isolation measures it brings. People are now working from 顺心彩票 office, and every walks of life are pausing their usual work and life.
How about the booming exponential rise in COVID-19 researches? But a shut downed administrative team of the publishing office? And the loss of manpower towards battle over the. COVID-19 frontline?
With the limited journal space, will timely researches be delayed in publication? Which may miss out important messages towards the public!
Peer Review: Publishing in the time of COVID-19
What's your view?
Yes, I expect a delay in the publishing process under COVID-19.
- Apr 17, 2020
WHat do you think is the correlation? It's impact? and the possible transmission route?
Neurologic Features in Severe SARS-CoV-2 Infection
- Mar 27, 2020
I would like to understand in what cases blood or some other biological liquid passes through implant or graft with some porous microstructure according the Darcy law (thanks to the pressure differences).
I have an idea to produce a research about blood permeability through various implants microstructure, but unfortunately it is harder than I thought to found some justification in literature that blood actually could pass through such microstructure due the Darcy law. Thus, I would be grateful for your help in this question - maybe you have some papers about it or some other helpful stuff.
Thank You Mr Bayan for this valuable book: Bio-materials in Clinical Practice, Advances in Clinical Research and Medical Devices
Part I Material Classes
Part II Bio-material Properties and Characterization
Part III Clinical Applications
Part II includes the article: Computer Modeling of Stent Deployment in the Coronary Artery Coupled with Plaque Progression. It is very interesting Numerical solution but it does not present a valuable knowledge about blood flow through implants according to the Darcy law. It does not refer too Darcy law.
Stent deployment with plaque formation and progression for specific patient in coronary arteries is described considering blood flow in a hollow Arteries. Blood flow simulation is described by Navier-Stokes and continuity equations not by Darcy law.
- Apr 15, 2020
Many journal publishers are opening their COVID-19 researches for free to the public. Among them which are the most useful? Is more famous one the better one?
If you got a research on COVID-19 on hand, which one of the following will you submit to ?
Which one is easiest to accept your publication?
Please vote as you like!
Other than those common opened platform below, you can also suggest any new ones you think is useful for COVID-19 research.
I will usually prefer to publish Coronavirus paper in journals related to Microbiology, Medicine, and Public Health
- Apr 13, 2020
Many of us are doing ongoing prospective research, yet COVID-19 has paused our work for a while or even months because of the city shut-down. There is an unexpected huge increase in lost to follow-up in our research clinics.
How should we deal with these cases, and the associated data?
The selection bias caused by the lost to follow-up cannot be adjusted by study design, as it is started already. What methods can we use to adjust instead?
Can anyone simply explain how inverse probability-of-censoring weighted estimation technique work on this issue?
How to run it practically, e.g. by SPSS software? Or other higher level of statistical software is needed?
How about stratification-based methods or weighted methods? How are they working actually?
Any practical guide available online?
Great thanks in advance with all your help!
The missing is likely random as affected by COVID-19. However, surgery groups tends to have less lost to follow up than medical treatment group
- Mar 6, 2018
Being invited to be reviewer for a conference or to be speaker is tempting for most young scientists. Not being aware of this businessplan I unfortunately accepted to review abstracts for one of such conference. Googleing around I realised I am not alone and that there are also several people wondering whether they should attend a conference or not as they are unsure if the organisers are genuine or not.
There are lists of predatory journals (e.g. https://predatoryjournals.com/journals/) but I did not find a good or comprehensive list of predatory conferences. So lets discuss such invitations to get a sense for those that can be trusted:
2nd annual Pharmacology & Toxicology Conference
Organized by KEI scammers, which appears to be highly populated by former OMICS scammers.
They continue to contact me no matter how many times I have unsubscribed or asked to be removed from their spam mails.
Have you thought about participating in the?2nd annual Pharmacology & Toxicology Conference next January? Would you like me to send you the updated scientific program?
Early registration closes on May 1 and we are hoping to fill a few remaining keynote speaker slots by then.
From:?P. Jimenez,?Ph.D. Sent:?Friday, March 27, 2020 To:?randolph.caldwell@ Subject:?Paris on 1/16/2021 ?
I am hoping we can discuss the idea of you presenting at the 2nd Pharmacology & Toxicology Conference (January 16 at Paris-Sorbonne University). This year's conference in Vienna provided an interesting insight into the recent advancements in the fields and was a great experience both for clinicians and researchers.?
The conference can provide hotel accommodation for speakers, and travel support is available.?I would be happy to send you an invitation letter if you require one.
These are some of the keynote presentations which will be part of the plenary session. We are also planning nine sessions with a more narrow focus.
- Pharmacological Anti-Ageing Interventions for Cancer Prevention
- Smart nanocarrier-based drug delivery systems for cancer therapy
- Emerging pharmacological targets for the treatment of diabetes
- Pharmacotherapy of postpartum depression: novel drug development
- Pharmacogenomic Considerations in the Treatment of HIV Infection
More information is available on the?conference website at?https://conferences.aoamj.org/pharmacology2021/
May I send you a copy of the preliminary program?
2nd Pharmacology & Toxicology Conference?
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- Apr 2, 2020
Ventilator is running out of supply under COVID-19, especially severely ill patients require non-invasive or even invasive ventilator support.
When there is outbreak of COVID-19 locally, physicians are facing the difficulties to choose between different patients for the allocation of limited medical resources.
Is there any simple way to turn something on hand to a usable ventilation machine? No matter household electronic gadgets, e.g. fan, vacuum cleaner, or existing medical equipment.
Will this extension increase the dead space of the breathing system, and weaken the ventilation?
What is the infection risk with this arrangement?
- Apr 8, 2020
When not inside an infected cell or in the process of infecting a cell, viruses exist in the form of independent particles, or virions, consisting of: (i) the genetic material, i.e. long molecules of DNA or RNA that encode the structure of the proteins by which the virus acts; (ii) a protein coat, the capsid, which surrounds and protects the genetic material; and in some cases (iii) an outside envelope of lipids. The shapes of these virus particles range from simple helical and icosahedral forms to more complex structures. Most virus species have virions too small to be seen with an optical microscope, about one hundredth the size of most bacteria.
Please have a look at this useful link.
- Apr 1, 2020
I am involved in a post graduate programme in medicine. I observed but in all modules where self-directed learning has been applied, students are not progressing as expected. My thinking was may be our transition was not well done. Any input well-appreciated.
Why is Self-Directed Learning the Better Approach?
With a variety of methods, for example, goal-based learning, that facilitate the self-directed approach as well as the ability to guide your own learning experience, self-directed learning already seems like the more appealing approach. Let’s delve a little deeper and consider some of the practical benefits of embarking upon a self-directed learning journey and, how this method not only impacts learners but, their organization as well.
The learner has complete control:
By choosing learning activities directly in line with their own interests/meet the needs of their end-goal, learners are more likely to engage with the content and therefore, take away beneficial points of interest to help better perform in their job role.
Rooted in the application of skills:
With SDL, learners are required to grasp the “how” and the “why” rather than the “what”. These acquired skills can then be utilized throughout their role for example, problem-solving, time management and communication skills.
Fosters a collaborative learning environment:
The social element of Curatr allows learners to interact with one another throughout their learning journeys. Subjects, problems and solutions can be debated by all learners and, ultimately, this encourages learners to learn from their colleagues and peers, creating a combined knowledge throughout an organization.
Meets individual learners needs:
SDL facilitates learning at one’s own pace. Relevance also increases because learners are motivated to learn from their own experiences while applying their newly-acquired knowledge to the job in hand.
A more convenient approach:
Through SDL, learners have the ability to learn whenever and wherever – for instance, listening to a podcast in the car, reading a short article on the train. Mobile versions help facilitate this possibility and, learning becomes much more manageable for learners to fit into the working week.
Overcoming the Pitfalls of SDL
Like with any learning approach, there are a few drawbacks to be mindful of when implementing the strategy into your organizations learning environment.
Loss of motivation:
With this approach, learners are now accountable for their own learning and, there is a risk that learners could lose motivation to continue. To overcome this, it offers the reflection feature that encourages learners to engage with their learning content, thinking back on what they have actually learned and the benefits of the learning material from a continuing professional development point of view.
- Mar 28, 2020
Many efforts are spent to prevent, treat and stop COVID-19 spread.
but I think these efforts are fragmentary and not organized.
there is no platform for a scientific collaboration that could shorten the time of interesting findings, some nations hide some facts are a privilege of authorship or for other political reasons.
I think that all countries should a global platform for scientific collaboration.
Personally I have some ideas that could be proposed for the treatment of COVID-19 based on scientific facts but with the innovative mode of application, how and where can I try to apply them?
All nations should avoid wasting their time to find a solution for COVID-19 without international collaboration.
Thats a very good idea to unite and make joint efforts to defeat the pandemic the world is suffering.
- Mar 12, 2020
With the developing stories of the spread of COVID-19 all around the world, which has been declared as a pandemic by WHO recently, I am wondering, in how much time this virus would vanish from the surface of the Earth? Is there any scientific study available for this?
Please share your opinions.
Till development of an effective vaccine.
- Apr 1, 2020
till india is in second phase, as per world patient data india spreading rate is very low. but it may increase exponential. what you think about outbreak of corona virus in india.
It is difficult to predict, but India is doing far better compared to other coronavirus (COVID-19) affected countries of the world.
- Apr 1, 2020
I am conducting a research project to see whether demographic/patient factors can predict patients who are likely to suffer a post-operative death (Categorical outcome Y/N).
I have conducted univariate regression procedure using SPSS Firths regression as I have a small sample size with the dependant variable being a sparse event. This has given me 3-4 variables with P<0.10.
DO I now proceed to perform a multi-logistic regression? If so, do I run Firths regression with all of these variables selected as co-variates or do I perform a more traditional multi-nominal regression model instead?
Any help would be appreciated as I can't find any guidance on this issue.
You didn't indicate how small a number the less-observed outcome was for your data set. If it's 100 or more, I wouldn't worry at all about using ordinary logistic regression. If 50-80, then LR may be fine if you have only a modest number of IVs in your model. If it's, say, 10 or fewer, then you're better off sticking with Firth method or some adjustment thereto (see link below). There are other, penalty-added methods available; I just don't know how they might perform with your data.
It's possible that someone has done a simulation study that includes conditions that match well to your data set. If not, you could always try that, to be more confident about your ultimate choice.
Good luck with your work.
- Mar 31, 2020
Viruses can not be killed. If so does a person infected from CoViD-19 doesn't acts as a carrier after his cure?
That is if a person is infected with CoViD-19 and he is been cured by the medicine, does he has that virus in his body in deactivated form? Or the body kills the virus by phagocytosis by the WBC's?
- Mar 29, 2020
COVID-19 is affecting all kinds of human activities, research is not exempted. Many ongoing research studies are not paused because of COVID-19, patient recruitment cannot be continued, follow up visits are not stict to schedule, intervention procedures may be delayed, blood test monitor are postponed.
I would expect a higher loss to follow up rate during this period, which would affect the reliability of research. Even after COVID-19, will the recruited subjects have some difference than those recruited before?
What do you think?
I am in a contiuous activities during this mandatory vacation but at 顺心彩票 office..
Wish you all healthy life.
- Mar 19, 2020
I ruminated a consideration on this proposal for the last couple of days as Germany is in anticipation of the surge.
To be clear: This is also just a theoretical exercise and – if applied - would count as a desperate measure in the case of patients otherwise not being ventilated at all.
What if the mode of ventilation chosen would not be conventional BIPAP but APRV/inverse ratio PCV?
The control parameters correspond to conventional ventilator settings as follows: P-high (P-insp), P-low (PEEP), T-high (insp. Time), T-low (exp. time) and FiO2. Note that implementing this mode of ventilation with conventional BIPAP, which is possible in some devices, will in some setups require calculation of respiratory rate, which is 60/(Thigh+Tlow). The slightly different terminology as well as specific algorithms for implementation have been characterized and properly published by experts in the field – which I am NOT. There have been promising studies in ARDS which I will attach below.
If one assumes that for two (or more) patients the key treatment goal would be oxygenation with a more liberal approach to CO2 removal, it should be possible to choose P-high, FiO2 and to some degree T-low to achieve safe oxygenation margins for both patients. This would still allow for some inhomogeneity in compliance between the patients as the lung is splinted to a rather high point in the P-V curve by P-high resulting in a high resting volume. This is the proposed “open-lung” aspect of this ventilation mode. Nevertheless, due to the sparse and brief passive pressure relief phases it is believed to go without higher frequency repeated expansion like in conventional PCV, resulting in less energy deposition into the tissue. The repeated overinflation/atelectasis due to inhomogeneos P-V dependencies had been my main concern when thinking about PCV in a shared circuit and a possible result of volutrauma/atelectotrauma in the patients.
In case of inhomogeneous severity between the patients/different disease progression the treatment goal could be set for the more severe patient accepting hyperoxia in the “more well” patient. In terms of CO2 removal a “common ground” target for the patients could be set in wider range of acceptable values, opting for permissive hypercapnia. As the passive release of the lung volume to exhalation in T-low will generate outflow which is cropped at a certain level of peak flow (by setting T-low) when conventionally setting up/adjusting this mode, it might be difficult to assess this control parameter for the individual patient in a shared circuit.
APRV does even allow for spontaneous breathing on P-high in weaning approaches which have been proposed as well. If flow for the device serving two patients would be dialed high enough to compensate for potential maximum inspiratory peak flow generated by both patients in spontaneous breathing, it could be fathomable to even conduct weaning with two spontaneously breathing patients sharing the same circuit.
I write this as I feel we are all staring in a potential abyss, which might force us to make choices that neither of us ever wanted to make.
Hence, this is a THEORETICAL CONSIDERATION and not a recommendation. Also I do not take any legal responsibility if patient harm ensues. I hope everybody understands that. Also probably someone already thought of this. But I thought: Sharing is caring.
Take care and stay strong.
Cane RD, Peruzzi WT, Shapiro BA. Airway pressure release ventilation in severe acute respiratory failure. Chest, Aug 1991: 100 (2); 460-3 Fergson ND, et al. High-frequency oscillation in early acute respiratory distress syndrome. New England Journal of Medicine 2013, 368 (9), 795-804 Frawley PM, Habashi NM. Airway pressure release ventilation: theory and practice. AACN Clinical Issues, 2001: 12 (2); 234-246 Garner W, Downs JB, Stock MC et al. Airway pressure release ventilation (APRV). A human trial. Chest, Oct 1988: 94 (4); 779-81 Habashi NM. Other approaches to open-lung ventilation: Airway pressure release ventilation. Crit Care Med 2005 Vol 33, No. 3 (suppl.) Maxwell RA, Green JM, Waldrop J et al. A randomized prospective trial of airway pressure release ventilation and low tidal volume ventilation in adult trauma patients with acute respiratory failure. The Journal of Trauma, Injury, Infection and Critical Care, 2010: 69; 501-511 Modrykamien A, Chatburn RL, Ashton RW. Airway pressure release ventilation: an alternative mode of mechanical ventilation in acute respiratory distress syndrome. Cleveland Clinic Journal of Medicine, 2011: 78 (2); 101-110 Rasanen J, Cane RD, Downs JB et al. Airway pressure release ventilation during acute lung injury: a prospective multicenter trial. Critical Care Medicine, Oct 1991: 19 (10); 1234-41 Roy S, et al. Early airway pressure release ventilation prevents ADRS – a novel preventative approach to lung injury. Shock 2013, 39 (1), 28-38
The Society of Critical Care Medicine (SCCM) has provided guidance on treating two patients with a single ventilator.
Society of Critical Care Medicine. Working protocol for supporting two patients with a single ventilator. Society of Critical Care Medicine. 2020. https://www.gnyha.org/news/working-protocol-for-supporting-two-patients-with-a-single-ventilator/
Anaesthesia machines can also be used as ICU ventilators. The SCCM has also provided guidance on this.
Society of Critical Care Medicine. Purposing anesthesia machines for ventilators. Society of Critical Care Medicine, 2020. https://www.asahq.org/in-the-spotlight/coronavirus-covid-19-information/purposing-anesthesia-machines-for-ventilators
However it is not possible to deliver APRV via an anaesthesia machine.
- Mar 27, 2020
Bickel (2009) describes those who remain robust under stress as resilient. Those who can rapidly adapt to change in times of stress are resilient. So, my question to you is, how are you? How are you coping? Are you thriving? Make sure you have seen this -> https://youtu.be/CCe5PaeAeew
Bickel, J. (2009). Faculty resilience and career development: Strategies for strengthening academic medicine. In Faculty Health in Academic Medicine (pp. 83-92). Humana Press.
Poor communication with a new world called viruses, and not taking things seriously seriously with the influence of the media
Need music and some resitfor our brain far away Corona virous
- Mar 25, 2020
Working in the research field, you will be weighted by your h-index.
However, publications might not be cited by others despite your hard work.
Do you think we should publish only citable research or publish as many as we could to contribute the academic field?
- Mar 14, 2014
Yes, smoke from the burning dried leaves of Calotropis procera is inhaled for the cure of cough and asthma.
- Oct 3, 2013
In my country, general practitioners also provide (sell) the medicine. What do you think of this practice? Please share your views concerning the advantages or disadvantages of this practice.
Do you know of places where it started like this; and then changed so that only pharmacists can dispense medicine? Thanks.
In the first place they are most trusted by locals. The medicine is usually effective but d problem is often with the posology. Every practitioner gives as per their knowledge which limits sustainability.
- Mar 18, 2020
Why is the INDIAN GRANATE used in medicine. Do you know which medicines?
Momordica charantia has a number of purported uses including cancer prevention, treatment of diabetes, fever, HIV and AIDS, and infections. While it has shown some potential clinical activity in laboratory experiments, "further studies are required to recommend its use".
- Mar 16, 2020
Does anyone know in which species the grass allergen Phl p5 occurs? It was originally isolated from the grass species Phleum pratense so it must at least occur in that species. It stand to reason that it might also occur in other species of the genus Phleum. A few papers states that it is universal in many grasses, but with poor documentation.
Can anyone provide conclusive evidence and/or references in which the authors state in which species (or cultivars) the allergen occurs and/or have been isolated from? I welcome answers from all researchers along with special interest from expert knowledge primarily from plant ecology, aerobiology, immunology and other health professionals.
Take a look at the following link.
- Mar 12, 2020
I am facing a problem when I try to calculate the hr from two different survival curves, here is the problem: in the first plot the experimental group's curve is more close to the placebo group then the second plot, even if the first plot's hr is smaller than the second plot. I wonder what the possible reasons are. Can you guys help me to solve this problem? Thanks.
It's hard to help without seeing the survival curves (Kaplan-Meier plot). Do you have one you can show us? Here's a video if you are not sure what I am talking about: https://www.youtube.com/watch?v=XDdytnv6HYE&list=PL64SCLAD3d1GJJrZ63sJGWALO22ZY9erG&index=27&t=1s
- Mar 11, 2020
Oncology is a branch of medicine that deals with the prevention, diagnosis, and treatment of cancer. A medical professional who practices oncology is an oncologist. The name's etymological origin is the Greek word ?γκο? (óngkos), meaning 1. "burden, volume, mass" and 2. "barb", and the Greek word λ?γο? (logos), meaning "study".
Cancer survival has improved due to three main components: improved prevention efforts to reduce exposure to risk factors (e.g., tobacco smoking and alcohol consumption), improved screening of several cancers (allowing for earlier diagnosis), and improvements in treatment.
For clinical oncology the textbook by DeVita is probably the most comprehensive and clear.
For molecular oncology seek the book by Bruchar. It is a little old but it seems still good.
- Mar 6, 2020
The presence of alloys and their use in medicine was one of the most important events and achievements in medicine. Do you think that the mechanism can change to amend this achievement?
Thank you so much for prof Andrew Paul McKenzie
- Mar 4, 2020
Dear Research Gate Members,
It has been observed worldwide that the individual with weak immune system can be easily attacked by Novel Corona Virus (COVID-19). The prominent health experts are also suggesting to improve immune system against Novel Corona Virus (COVID-19).
Please, share your expert suggestions on the following question.
How can we strengthen our immune system to fight against Novel Corona Virus (COVID-19) spread?
Thanks & Regards
Regular eating raw garlic strengthen the immune system of the body.
- Feb 27, 2020
Deleted by Research Gate....
Edited 2020-10-09: the reason one might find in Reply 001 of this particular compensational thread
I contacted RG support about that thread, and after a first email telling me how to report a thread or post, I told them that I was reporting THEM, RG, for removal of that discussion thread. This is what they wrote back:
Thanks for the clarification. Please note that we may remove a question or discussion if there are any violations of our terms or guidelines. For privacy reasons, we cannot provide additional information regarding any actions taken in relation to other members' posts.
RG Community Support
Chausseestr. 20, 10115 Berlin, Germany
Only problem is, there are no terms of service against discussing the frauds and predators of the publishing/conference organizing world. All I can find is that outside the US, German laws prevail and Germany has some very outdated laws concerning "insults". The problem is, they have even clearer laws (Unfair Competition Act or UWG, and Telemedia or BSI Act) concerning the business practices of the fraudsters, as in all those unwanted emails we get sent that fraudulently claim presenters and sponsors, especially after telling the email spammers for years to cease and desist.
So KEI, like OMICS (which was fined $50million in the US for their fraudulent business practices), is violating Germany's UWG on a daily basis according to the various threads to date, and especially the one deleted. That deletion was particularly heinous in that it deleted the first hand experiences of people who had been to a predatory for-profit conference and gave details.
And again RG, I have been sent promotional material by KEI operatives trying to get me to sign up to speak at a KEI conference. In that promotional material sent by digital transmission, KEI claimed Keynote Presenters and speakers in their effort to get me to join. I have proof that at least three of those people were fraudulently listed to try to get me and others to sign up, were not attending and were unaware that their names were being published (digital media) as speakers for promotional purposes. As in, they never registered or agreed and yet KEI claimed them which is a violation of the UWG, at least three different paragraphs worth.
- Sep 3, 2014
PPI affect CYP system while clopidogrel depend on this system to be converted to its active form. (controversy issue)
Proton pump inhibitors (PPIs) inhibits enzyme CYP 2C19 interfering with the conversion of clopidogrel into its active metabolite. Studies document the possible interaction of clopidogrel and PPIs leading to a decrease in the antiplatelet efficacy of clopidogrel.
- Feb 20, 2020
I am aware this is a rather odd question but I couldn’t find any answers to this in the literature. One study has used sperm cells as a drug delivery tool (see below) but I was wondering if it might have broader implications. Would sperm injected into the bloodstream survive for long? What about if it was taken orally? Would appreciate any thoughts!
Sperm is typically prevented from exposure to blood - because even a male's own sperm is seen by their immune system as "foreign", leading to the formation of anti-sperm antibodies. This can be a problem in clinical situations such as after testicular trauma, leading to infertility.
As such, I dont think sperm delivery into the bloodstream is practical and although I dont have any specific data on it, I believe the survival of sperm in the blood stream would not be very long. The article you have linked to seems to be suggesting the utility of a sperm delivery system for anti-tumour therapy into the female genital tract (in the lumen, not via the bloodstream) to treat malignancies like endometrial cancer. I couldnt access the full text, so not sure how rigiriusly they have tested this - certainly sounds like an interesting idea!
- Jan 16, 2020
A more advanced method of training would be to perform explosive medicine ball exercises after a weightlifting exercise, i.e. Cleans or Back Squats followed by a medicine ball vertical toss. This method of training is more commonly known as complex training
I don't fully understand what's your question about and what do you mean by athletic power development? is it about development of peak power output in a sport specific movements? Proper, complex training involves a combination of high-loaded resistance exercise followed by a biomechanically similar explosive activity, best if specific for particular sport discipline. Therefore, medicine balls seems to be great equipment for use in this method since they allow to do ballistic movements (another great method for power development).
- Feb 11, 2020
There is a continuing accusation by alternative medicine practitioners that their method cannot be proven or their proof is inadequate. The basic principles, diagnostic, nomenclature and medical methods of Western and alternative (eastern) medicine are different. The western is linear and reductive, the eastern is more network-oriented. These require different methods of statistical analysis. Can they be judged by an approach?
Yes, we always need to have the scientific research methods in mind but we need to be very wise while applying them, making sure the sistematic and Organization criteria are accomplished. That would be the only way to get consistent results and to measure the cost effectiveness of such a treatment.
- Jun 6, 2017
There was a proposal of a researcher who asked me to write down a paper which will more or less extend the poster (link bellow) published at ICCB 2016 in Prague. This all happened by an accident. I did not like to come at a conference without some presentation. Hence, I did quickly put the ideas that are resonating in my head for years on that poster to allow other researchers to benefit from it. Surprisingly, this poster is getting a great deal of attention. Therefore, I am thinking about to write down a review (prescription) how to design sel-organizing and emergennt systems with a rich example aparatus. If you like the idea then wisit the poster and let there a comment about it (bellow the poster).
The whole project is meant as a service to the community of biological and medical researchers who would like to know more but have no time to study mathematics and programming in depth.
All the best at your research,
- Jan 9, 2020
Simple search in Google Scholar shows that since 1960-70 many articles in peer-reviewed journals have supported various desirable effects of Transcendental Meditation (TM) but some people here and there claim that the research has always bee. Funded by certain organizations and people who benefit from advertising TM and the published evidences are not so reliable. Is that really true?
- Jan 25, 2020
theoretical biology and medicine using artificial intelligence and mathematics is an emerging field in biology and medicine based on big data from bioinformation and healthcare electronic record. Clinical practice heavily relies on individual experiences, which lead to bias in recognition, diagnosis and treatment of disease. In fact, theoretical analysis is vital for biology and medicine. For example, chronic persistent inflammation plays an important role in carcinogenesis and also take effects on cancer metastasis. Under this theory, cancer patients with smoking have a high risk for lung metastasis because smoking can induce primary lung cancer occurrence through activation of chronic inflammation pathway. carcinogenesis. Further, it can be concluded that any stimuli induced persistent injury should be identified and avoided for cancer patients.
Dynamic monitoring of various bioinformation such as body fluids using physical and chemical methods is another emerging field in medicine. For example, urine is easy to be collected, which indicates many signs of various diseases. If the urinalysis by current advanced techonogies is cheap and convenient, it will be helpful to find potential diseases. They will give accelerated advancement in cancer metastasis research and other fields in medicine.
- Jan 22, 2020
Dear colleagues! Your opinion, please! What are the ways and opportunities for registering orphan drugs? Thank you in advance for the information. Best regards Olga Shnaybel
Orphan drug. An orphan drug is a pharmaceutical agent developed to treat medical conditions which, because they are so rare, would not be profitable to produce without government assistance. The conditions are referred to as orphan diseases
Now an answer there are international rules that orphan drugs may just register, bu WHO.
- Jan 6, 2020
I am a Brazilian psychiatrist with a master degree in preventive medicine. This year I will coordinate an academic ambulatory for medical students. I would like to teach deprescribing in psychiatry. The students are in the final year of medicine degree, and they will spend one month in this ambulatory. The ambulatory is part of a primary care setting which don’t have psychiatrists or other specialists. So, my major difficult is how to select patients? Which patients would benefit of this approach? Anyone has previous experience or suggestion??
Cássio Henrique Gomide Papa - I recommend reading the presentation by Lia Dolovich, Pharm D on teaching deprescribing and also the references listed in her presentation.
- Dec 30, 2019
If the aim is to approach to the target. Why do we use "precision medicine" instead of "accurate medicine" ?
It is not just about accuracy. Precision medicine is targeted, and tailored -on molecular level- for each patient.
- Jan 1, 2020
There are a lot of problems in medicine that needs the newest technologies in computer science fields like Machine Learning and Deep Learning to solve them.
Can anyone mention some of these problems that are unsolved till now?
Let's start with a field that I know the best: biosignals processing, clarification, and prediction. There are many unresolved problems like
* Prediction of arrhythmias
* Prediction of epileptic seizures
* Reconstruction of physiological interdependencies of various physiological processes using biosignals.
* Reconstruction of physiological paths in the brain from biosignals.
* Assessing the health condition of people using biosignals.
We can do the following research
* Data mining for disease-genome dependencies from available databases.
* Prediction of disease spreads using internet searches.
* Assessment of the population health using internet searches.
* Cross AI methods with deep knowledge of complex systems theory and apply it to medicine -- this is my area of research.
* Study and predict drug interactions and side effects in patients. This will save a lot of unnecessary suffering in those using medical drugs.
* The above can be supported by an active search through all available data for possible, future drug interactions prior to their application to patients.
* Such research can help medical doctors to avoid deadly or highly damaging drug interactions. Each patient reacts differently to the same drugs! We need to know why and especially when it happens!
* Start development of advanced AI methods tailored towards the needs of bio-medicine.
All the above depends on how reliable databases of biosignals, medical records, bio-imaging, laboratory results, and many other database build.
When you want to have successful research in the field of AI, perfect databases that are open-access are a must. We have an extreme shortage of those databases. You can build a very successful carrier by building such a database(s). :-)
This is just a short list of all possibilities. :-)
- Mar 6, 2019
53 Y F, last degree prolapsed uterus presents with four ulcers, 2 on the surface of the uterus, one on the surface of cervix and another one (Can't recall the location). There is daily discharge. What is the appropriate treatment to eliminate the discharge until she undergoes vaginal hysterectomy? Local antibiotic therapy or what?
Medications she takes:
Bisoprolol 2.5 mg once daily for Atrial Fibrillation
Cetirizine 10 mg once daily for Allergic Rhinitis
Daflon 500 mg once daily for chronic venous insufficiency
Non-Alcoholic-Fatty liver disease (Not managed with medications)
Blood tests were done and no other abnormalities.
Local estrogen cream until the ulcer heals then proceed to vaginal hysterectomy
- Dec 16, 2019
I recently attended an Education Conference where they encouraged teachers to use VR in their classes. In most of the cases these were medicine courses, but is it possible to incorate that technology in accounting courses?
- Aug 9, 2019
What shall be the choice: manual or automatic? It is clear from research and practice that inaccuracies exist with automatic BP use while manual seem preferable or yet not really? Some claim that automatic exclude bias in measurement.
Inaccurate reads of blood pressure lead to consumption of medications otherwise not needed if blood pressure measurements would be accurate. It affects lives-health. Which BP monitor shall be used? Both? How to resolve this dilemma in our age of automatisation?
I know that much inquiries are made by me but its a life related investigation.
Thank you in advance for contributions.
Mirdamadi A, Etebari M. Comparison of manual versus automated blood pressure measurement in intensive care unit, coronary care unit, and emergency room. ARYA Atheroscler. 2017;13(1):29–34.
- Sep 13, 2019
The global average surface temperature rose 0.6 to 0.9 degrees Celsius (1.1 to 1.6° F) between 1906 and 2005, and the rate of temperature increase has nearly been doubled in the last 50 years. Temperatures are certain to go up further and may lead to fast genetic mutations in some pathogenic microbes to become accustomed to the new climate and proliferate resistant gene distribution over geographies. In addition, the overuses of antibiotics is also triggering the issues at a great step. Near about 10 most deadly bacterial pathogens have already been registered as antibiotic-resistant. Mycobacterium tuberculosis is one of them, that has already been created a huge challenge to overcome in their own right and will only become harder to control as their resistance to antibiotics grows. The development of new antibiotics is slow and difficult work but bacterial resistance is decreasing our arsenal of existing drugs posing a catastrophic threat as ordinary infections become untreatable.
- Dec 5, 2019
Human body is full of spatial fractals and temporal bifurcations. During treatment in medicine ( ultrasound, X-rays, photons, neutrons, ions...) in computerized tomography ( CT) is used nonlinear or locally linear ( linearized) theory ? It is on-line or off-line in different cases?
Computerized Tomography (CT) uses algebraic reconstruction technique (ART) which can be considered as an iterative solver of a system of linear equations. However, there exists nonlinear iterative algorithms for CT such as multiplicative algebraic reconstruction technique (MART) and experiments have shown that it can indeed further optimize CT algorithms resulting in greater image quality and dose reduction:
To answer your second question, it can be online, offline or even hybrid depending on the case.
- Nov 12, 2019
Is it possible to use a medical computed tomography (CT) machine for the inspection of 3D printed parts?
I think there is no problem in using CT for medical field. An industrial computed tomography (CT) scan can validate and qualify prototypes and the first printed parts for many different materials such as mold components, metal or plastic printed parts. Industrial CT scanning is able to validate internal geometry and defects within a part without destroying the part. From the two-dimensional X-ray images, the CT system is able to generate a 3D image for both the interior and exterior of the part. The 3D image may represent 3D volumetric density map in gray values based on the different composition of the sample.
CT-scan with 66 μm nominal voxel size can be useful to complaiance with X-Ray in diagnosing the Porosity analysis of 3D printed plastic parts. Decreasing the voxel size will improve the reliability of pore detection, but will also cost extra time and expenses for the CT-scan, reconstruction, evaluation and in storage. In particular, the X ray computed tomography (CT) inspection technologies show several advantages as a non-destructive method for acquiring structural characterization of both internal and external geometries of AM parts, and it might be the only available option to extract component dimensions of internal or hidden features that are inaccessible to well established metrology tools. This makes the CT technology a good partner in the “3D printing revolution” for the study and inspection of AM products. Of course, the ability of defect detection by X-ray CT has a direct correlation with the size, complexity, and type of material of the part being analyzed, but in principle high scanning resolutions are possible, from millimeters to micrometers, and more recently nanometers.
Please go through one of the references cited below.
A. Thompson, L. K?rner, N. Senin, S. Lawes, I. Maskery, R. Leach (2017): Measuremnet of internal surfaces of additively manufactured parts by X-ray computed tomography. Conference on Industrial Computed tomography 2017, Leuven/Belgium
- Nov 18, 2019
A patient with hereditary desminopathy (Thr341Pro DES mutation in a heterozygous state) was recommended to refuse toothpaste. He continued to brush his teeth twice a day with a toothbrush with only water. As a result, within one month we noted a significant increase in strength and muscle mass in this patient. The patient did not take any medications during this period. After 30 days, the muscle condition returned to its original level. How can this positive effect be explained?
Another possible explanation would be that the patient's refrain from using the toothpaste lead to an increased level of plasma nitrate, which helped improve sympatholysis; thus, alleviating (possible) functional muscle ischaemia.
- Nov 14, 2013
Some may have normal iron level.
Yes, we do it for confirmation.
Daily iron and folic acid supplementation during pregnancy
Daily oral iron and folic acid supplementation with 30 mg to 60 mg of elemental irona and 400 μg (0.4 mg) folic acidb is recommended for pregnant women to prevent maternal anaemia, puerperal sepsis, low birth weight, and preterm birth.
a The equivalent of 60 mg of elemental iron is 300 mg ferrous sulfate heptahydrate, 180 mg ferrous fumarate or 500 mg of ferrous gluconate. b Folic acid should be commenced as early as possible (ideally before conception) to prevent neural tube defects
- Nov 8, 2019
Could we call published papers from all disciplines as SCIENTIFIC PAPER or just we say it for physics, biology, chemistry, mathematics, engineering, medicine or related things whereas linguistics or i.e. history is same?
Dear Muhammad Shehryar Sabir, Mubasher Rehman, Thierry Olive thank you for your valuable answers, however, I meant that when you want to write a research in literature, history or education you need references, desk and possible questionnaire. Thus your research may not be similar to another in another place, but when there are scientific experiments which must be reproducible in other place in the world, therefore in the first case, it is a research study (research paper) while the second case is scientific research (scientific paper).
- May 21, 2019
- Oct 14, 2019
Eating in illness
Eating the right food serves as preventative medicine in times of health, and during illness serves still as medicine however needs will be different. Fasting is quite often the call with simple illnesses which if we deal with in the correct way then more serious illnesses should be kept away.
- Oct 19, 2019
The modern world is returning back to the nature! Organic/ Natural/ Unprocessed/ Wholemeal foods for good health, longevity - have become a craze now. But in case of treatment and prophylaxis - why do everyone opts for allopathic (the science based modern) medicine? Why not first the traditionals: Ayurveda/ Homeopathy/ Oriental/ Herbal/ Naturopathy/ Acupuncture/ Massage/ Yoga/ Dietary etc?
Aren't these scientific enough? Are they developing in appropriate pace with allopathy?
Why do modern clinicians still neglect/tease some of theses modes of therapies?
Why the new generation not getting solid confidence on these natural treatments?
@ Dr. Md Rabiul Alam
In rural and semi-urban India, traditional medicines are still the first option for treatment of diseases. People of all generations understand the importance of traditional medicines, that's why they are gradually shifting towards natural and plant based medicines as stated by Professor Amit Baran Sharangi Sir in his post.
- Aug 4, 2019
The involvement of excessive statistical terms made the Medical research difficult. A doctor remain most of the time busy in clinical practice. The involvement of unnecessary statistical tests and terms made research difficult for Doctors of Medicine. Moreover, it is experienced that Statisticians only keep the medical students confused in unnecessary formulas and terminologies but don't teach them the software like SPSS to evaluate their data their-selves. After cramming a lot of the statistical formula passing the subject of bio-statistics the student remain dependent on statistician for the analysis of data. Am I wrong? (it is my personal opinion)
That's why the role of Bio/ medical statistician is important, as a good Biostatistician make it easy, and discusses in understandable language.
- Aug 16, 2019
What are the conceptual bases for personalised nutrition?
Please check these articles...
- Jul 29, 2019
A scientist job is very much energy consuming. Extensive work of Academic teaching, day to day designing new experiments, mentoring students and publishing research etc result in some serious health issues including stress, obesity, high BP etc. The food thy eat should also act as a medicine. So what are the best food supplements those must be used by scientists for the optimal performance during job.
- Oct 2, 2019
- Jun 5, 2018
Do you know any medicinal properties of chlorophyll?
Please share your ideas
Photo-synthetic phosphorylation through PSI & PS II . It is a Mg - Porphyrin Che elate Complex or Called Antenna , absorbs Photon for the above light reaction
utilizing CO2 to synthesize carbohydrate & producing OXYGEN for our respiration .
- Sep 20, 2019
Anyone who expert in this topic...
It is expected that participants who will engage in medicine ball exercises will determine better performance in horizontal jumps. Participants who will not take part in medicine ball exercises will have trouble with horizontal jumps. Participants who will engage in medicine ball exercises will prove more explosive power and overall body strength which will improve their ability to make horizontal jumps.
- Sep 10, 2019
Any suggestions please! !
Clinical audit is a quality improvement process that seeks to improve patient care and outcomes through systematic review of care against explicit criteria…Where indicated, changes are implemented…and further monitoring is used to confirm improvement in healthcare delivery.”
Principles for Best Practice in Clinical Audit (2002, NICE/CHI)
1. Clinical audit is not just a data collection exercise: ? It involves measuring current patient care and outcomes against explicit audit criteria (also termed standards). ? There is an expectation from the outset that practice will be improved.
2. Further clinical audit may be required to confirm that practice has improved. The main stages of the clinical audit process are:
1) Selecting a topic.
2) Agreeing standards of best practice (audit criteria).
3) Collecting data.
4) Analysing data against standards.
5) Feeding back results.
6) Discussing possible changes.
7) Implementing agreed changes.
8) Allowing time for changes to embed before re-auditing.
9) Collecting a second set of data.
10) Analysing the re-audit data.
11) Feeding back the re-audit results.
12) Discussing whether practice has improved
Some of the topics were below:
Further reading will be useful
I hope it will help
- Sep 6, 2019
This because table sugar is extracted naturally from sugar cane or sugar beets and hydrolyzed to glucose and fructose and never could reach the body cells in its origin form. The hydrolysis process occurs in mouth, stomach and small intestine which the products of sucrose in body may be in a similar manner to that of honey and bread. In other words, sucrose is a carbohydrate that occurs naturally in every fruit and vegetable. But, why there is no similar propaganda to the not natural synthesized chemical candy such as aspartame and so on.
- Sep 7, 2019
I think this one question is actually a combination of various different questions and assumptions.
The fact that sugar is extracted from "natural sources" such as sugar beets and sugar cane does not mean that it "good", just because of its natural origin. Likewise, you cannot say that "artificial" sweeteners are "bad", just because they are "artifical". You probably also would not say that cocain is a good thing, just because it can be extracted from plants....
In my opinion the problem is that in the modern Western diet, people consume extremely high amounts of fat and sugar. There is also an increasing use of high-fructose-corn syrup and similar products. If you buy, for example, a modern joghurt with fruit (flavour), it contains > 10% sugar. If you look at "sweets" for kids, they often contain 30% - 50% of sugar. Therefore, the "density" of sugar much higher that in fruits or vegetables.
It is probably difficult to eat so many fruits and vegetables to get similar amounts of sugar. But if you would, for example by eating huge amounts of honey and dates every day, this also would not be good for your health. At least in Europe, nutritionists warn people that also intake of too much "natural sugar" (milk products, fruit juices) can cause health problems.
You also mentioned sweeteners such as aspartam and asked why nobody is complaining about them. First of all, these products are much sweeter than sucrose or fructose, so there are much smaller amounts used. Second, there are people in both Europe and the US who warn customers not to use such products.
In summary, I would say that eating huge amounts of sugar is not good for your health, no matter if it comes from fruit, vegetables or modern "convenince foods". The peoblem seems to be that modern food is just unnaturally high in sugar and people, therefore, consume much lager amounts of sure than decades ago.
- Aug 28, 2019
In a patient with hereditary desminopathy (Thr341Pro DES mutation in the heterozygous state), a significant loss of muscle mass is observed after a night's sleep, with its replacement by adipose tissue. How to reduce muscle loss during sleep?
Dear Ali Javadmanesh, Adrian Fierl, Abdulnabi Abdullamer Matruod, thank you very much for your answers!
- Nov 29, 2018
Generally PH Level, TFM, Apart wish to have healthy discussion in the aspect of revealing what all are the major metric, Qualitative, Quantitative factor we need to consider in cosmetic products and research.
Batchwise qualitative and quantitative assay of the ingredients mentioned or claimed is required. Besides skin compatibility and carcinogenicity should be checked as a part of R&D
- Oct 27, 2018
Is there any website that can tell me when this adverse reaction will occur? For example, will this adverse reaction occur after repeated exposure? Or can occur after first dose? Or can be delayed?
- Jul 26, 2019
Like some syrups, can tablets and capsules be flavor coated? Especially for children and adults who can't take regular tablets or capsules. Are there any side effects for flavor-coating a tablet or capsule? Besides masking taste of the medicine, can the smell of medicine be masked?
- Oct 17, 2018
Autopsies show that there are two abnormal structures in the brain with AD called plaques and tangles. Plaques are made from a protein known as Beta-amyloid and tangles are made of Tau protein. These proteins also exist in a healthy brain. What make them to lose their normal function and cause the cell death?
- Jul 11, 2019
Why cant there be a journal dedicated to the field of medicine which does not yet have any experimental basis much like theoretical medicine?
- Jul 10, 2019
In most contexts, the terms alternative medicine, complementary medicine, integrative medicine, holistic medicine, natural medicine, and unconventional medicine are almost synonymous.
Everyday more patients seek non conventional approaches to their non resolved medical problems. Many of these approaches are safe and recommended by credited physicians. At the same time, conventional medicine discredits this therapies because of lack of demonstrative clinical studies.
I believe many non conventional therapies should be includes after judicious consideration, and serious clinical studies should be performed when a positive balance between (good) efficacy and (low) risk is perceived.
In this way, many today’s innocuous, non conventional therapies could precede more aggressive mainstream therapeutical approaches.
Two main factual problems should be taken in consideration:
First the lack of clinical studies comes from huge imbalance between private pharmaceutical funding and that of non conventional therapies. This brings up the ethical question: Is clinical research really at patient′s service or at the service of pharmacology?
Secondly, I believe that not only "scientifically" proven medicine acceptable. Good clinical sense should always come first, based when necessary but never exclusively on clinical studies. In this sense, we must remember that most of our conventional practice is based on "accepted" opinions and not in the so called "science”. Many of the cases because of obvious reasons ... nobody is refraining from performing CPR to a arrested patient, or ventilate a patient in critical respiratory failure just because no randomized, double blind, controlled studies were made to demonstrate its efficacy in that particular situation.
As a consequence my position is to approach non conventional medicines as an opportunity rather than as a problem.
- Feb 18, 2019
Many studies reported an association between nutrition and human hearing loss. These studies showed the incidence of hearing loss was increased with the lack of micro-nutrients such as vitamins A, B, C, E, zinc, magnesium, selenium and iron.Moreover, high carbohydrate, fat, and cholesterol intake, or lower protein intake, are responsible for poor hearing status.
Dear colleagues, Any more studies or experience about the relation between nutrition and hearing loss?
I think the following article will be useful
- Mar 22, 2019
Helicobacter pylori inhabit the gastrointestinal tract, one person’s poison may be another’s cure. Helicobacter pylori, the bacterium that causes gastric ulcers and stomach cancer in some people, may actually protect against cancer of the esophagus. So, What about your experience in the paradoxical effect of Helicobacter pylori infection? and why their resistance to treatment was increased?
- Apr 27, 2019
Coffee is a simple beverage, but it’s full of complex compounds with health benefits. It contains hundreds of bioactive components including vitamins, minerals, and anti-inflammatory polyphenols such as flavonoids. The amount of caffeine in a cup of coffee can vary, depending on factors ranging from the type of bean used. So, What about the healthy daily amount of caffeine was recommended to be healthy with no risk?
Four cups of coffee a day
- Jun 15, 2019
Every athlete requires an adequate amount of protein. It’s not only good to increase lean muscle mass , it will also optimize anabolic hormone levels, increase metabolism relative to other nutrients and improve cardiovascular risk profiles.
So which are better protein supplements or protein in foods ?
There are seven types shown in the following link
- Jun 23, 2019
Will nanotechnology solve the world problems such as water purification problem and delivery of medicine?
What about of its health and dangerous effects? How can nanotechnology domain with these potential effects?
Everything which is powerful has the risk to be dangerous, also it (nanotech) is slow paced. People may have sparkling word for the bright future or so, but we should realistically understand what we actually do, what our mentality is and what we are capable of. Nanotechnology will improve certain domain like water purification, delivery of medicine, that's the specialty of nanotechnology. But until or unless if u r not strong in any other domain its waste of choosing this. Nanotechnology alone won’t work; it’s all about application where u use it.