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It seem individual's attitude to environment are changing rather than last year due to corona virus issues and challenges. What do you think?
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Of course no. All actions of governments, organizations, companies, etc. now aimed at preserving and restoring of the formely existing realities (pre-covid...). Just talks.
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Throughout the world many scientists/researchers, globally hard working to develop relevant drugs/medicines for the treatment of COVID19. Can anyone tell, if there is development, regarding?
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In India, few medicines have been approved on emergency basis for the treatment/management of COVID 19. You can visit www.cdco. gov.in
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When it comes to Ambivalence, it can be a symptom of mental illness but it is also something we experience in our everyday life ( I certainly do, and my wife hates it) . Where would you draw the line between normal ambivalence and pathological ambivalence? The word is free..
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Ambivalence is a kind of protective suit our mind wears to avoid getting down into emotional pitfalls. "Ambivalence can serve as a means of self-protection"- Christian Wheeler. In fact, judgement accuracy can be increased by emotional ambivalence [Journal of Experimental Social Psychology 2013;49(3):360-7].
The line of demarcation is when ambivalence becomes a hindrance like baggage, which cannot be done away with. When our ability to move forward is affected, then possibly ambivalence has gone into the pathological mode. "Chronic ambivalence results in a rigid cycling pattern where we find ourselves constantly moving from one side of the decision fence to the other. When this happens, ambivalence becomes an emotional and psychological barrier to achieving genuine happiness" -Paula Durlofsky
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Dear Scholars,
You all are well aware that COVID-19 has disrupted every aspect of our lives including K12 and higher education sectors. Keeping in view the WHO recommendations, nations are enforcing social distancing in all fields including primary, secondary, higher secondary and university education. If we think positively, then this culprit COVID-19 is a blessing in disguise as the people are now taking care of personal hygiene, cleanliness of their surroundings and trying their best to improve their immunity. Besides educational institutions are reaching to the students.
During the past three months, the schools and universities around the globe have extended their outreach from a confined classroom to the students` bedrooms. Now the students can learn with more flexibility without wasting their times in travelling to their respective schools. The online mode of education has proven fruitful as it has lead to reduce institutional expenses which they had been spending on building & maintenance of infrastructure, electricity, furniture, multimedia and computing equipment. There is likelihood that tuition fee may be reduced with time if the situation prolongs (god forbid).
Apart from the above facts, I personally believe that online mode of education can not replace laboratory and clinical training of students who are pursuing their undergraduate studies in medicine, dentistry, engineering and such other technical fields.
What do you think? Will this batch of undergraduate students who are learning through online media i.e. LMS, Zoom, Webax etc, be able to acquire the professional competencies required in their respective fields. If the answer is no, then how can we utilize online platforms to ensure delivery of the quality education and achievement of course and program learning outcomes?
Thank you .
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Well said
Zorica Popovi?
I especially like the phrase "Mission Impossible"...
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The big five personality trait model ( McCrae & Costa) describes 5 bipolar dimensions of personality. The model received some criticism but is still generally accepted and perhaps it is the only descriptive model of personality that is "widely" accepted. What do you think are the strengths and weaknesses of this model? Is it complete or not? If not, what is missing?
Best wishes Henrik
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Dear Dr.Samah Zahran,
Please, add money to your greatest assessment for personality perspective..
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50 percent of physicians joined the Nazi party. For some reason, they were more enthusiastic than other professions to collaborate with Nazis. Other professions did not have such high representation in the Nazi party.
I wonder about the possible reasons for that enthusiasm.
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  • Udo.Hennighausen@web.de: I feel that there are several reasons. 1871 the Jewish citizens got full citizen rights in Germany (the Deutsche Reich) and many of them started an academic career. At the same time, in the last third of the 19th century, a latent antisemitism rose in Germany, in all levels of the society. The work in a hospital may be compared with the work on a ship, the leading physician, often professor, had a right to order similar to the captain of a ship. This military thinking might have been one cause for the adherence to NS. Also many medical students at that time were members of academic corporations (Burschenschaften, Landsmannschaften, Corps etc.), where also authoritarian rules were lived. Perhaps doctors were jealous on the job-positions of Yewish doctors, as after 1871 many Germans of Yewish heritage or faith started a successful academic career or profession in private practice. Rebecca Schwoch (Hamburg) has done a great research work about the fate of the doctors of Yewish heritage or faith in private practice with licence for social insurance, who worked in Berlin: About half of the doctors in private practice with licence for social insurance in Berlin were of Jewisch faith or heritage. Another point is the idea of eugenics, half science, half ideology, which was discussed in all countries at that time and was cultivated be NS-ideology.
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Hello, dear fellow scholars.
I'm writing this post after the advice that I received to bring to your knowledge a lesson that I'm learning yet at the beginning of my academic career.
I'm one of the authors of a case report that has been published by the journal 'Archives Of Medicine' without our consent1. Before the case report has been published, we have sent a formal e-mail soliciting to the editors the withdrawal of our intention to publish, because we have found that the journal was being investigated due to suspicious activities2.
I'm currently a 3rd-year medical school student and this was the first time that we have submitted an article to a journal (me and my colleague, which also is a 3rd-year medical school student). I'm mentioning this just to contextualize the fact that we are pretty much beginners in the matters of scientific publications and we never even imagined that such thing as "predatory publishers" exist.
When we started to look for journals to publish the case report, we were looking for a cost-free journal, but at the time we submitted the article to the Archives of Medicine, by an honest mistake and lack of attention, we didn't realize that this journal has a publishing fee, and a few days after we had submitted the case report we received an e-mail with a charging bill of over 1,500 euros.
Immediately after receiving this e-mail, we started to write a formal message to the editorial board, explaining to them about our mistake, apologizing for the inconvenience, and soliciting the withdrawal of the intent to publish the case report. Also, we got suspicious by the fact that this charging form was asking for sensitive financial information (like credit card number, CVV number, and other info).
In the meantime, we came across a post (here in Research Gate) mentioning the suspicious activities about the IMedPub2 (the group responsible for the Archives of Medicine). As soon as we found out these facts, we sent the e-mail formally soliciting the withdrawal of the intent to publish the case report. However, a few days later as I've mentioned at the beginning of this post, the journal published the case report1 without our consent and ignoring our solicitation. We have only completed the initial forms for starting the publishing process and send them the manuscript by completing the on-line form but we didn't make any payment for the publication fee since we sent this e-mail soliciting the withdrawal of the submitting intention (even though, the journal published it anyway).
1https://www.archivesofmedicine.com/medicine/atypical-case-of-chronic-granulomatous-disease-a-case-report.pdf
2http://www.fondpageant.com/post/Can_I_trust_OMICS_iMedPub_Conference_Series_Allied_Academies_Pulsus_Trade_Sci_SciTechnol_and_EuroSciCon
All this post was originated by the concern about the fact that our names are now associated with an article published by a journal that was under the accusation of suspicious activities and how this could affect our academic reputation and professional future.
We have received some advice to turn the situation public here in Research Gate to other researchers to learn from this lesson and also to hear your opinion. We'll appreciate it if you let us know your perspective about the case and if you can advise a better way of how to resolve this situation.
I apologize for this enormous text, but I think it was necessary to explain the whole situation with some more detail.
If you want to know more details about the original post, the link is the following: http://www.fondpageant.com/post/How_to_proceed_in_cases_of_violation_of_copyright
Thanks for your attention.
Best regards,
Wilian Sant'Ana
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Thank you for the tip! Surely I'll add it to my checklist next time.
Regards.
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The development of a vaccine for COVID-19 has become a battleground for many countries to prove to the world/their own peoples that their technology is superior and better than the competitors at the international stage. it is always a point of concern when science is serving the political establishment. WHO is raising concern about the validity of this claim and urging Russia to provide sufficient data to back this claim.
Is it possible for the same scenario to be repeated in the US? An election is near and COVID-19 vaccine development can influence the result.
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Is Russia's COVID-19 trials akin to "Haste makes waste"?
Russia's COVID-19 vaccine has not gone through the mill as some other vaccines, the front-runners being Chinese vaccine which is undergoing phase 3 trials in China, Brazil, Saudi Arabia and Pakistan, Oxford Astra-Zeneca vaccine, also in phase 3 trials, and Moderna's US vaccine.
I will just say regarding Russia's COVID-19 policy "Haste makes waste"
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I often hear from friends negative things about academia, its boring, not connected to reality etc. I have been on and off in academia for 25 years but for the most part I have been in the real world, running businesses and working as a business consultant. I can still feel that in academia there is at least in my field a theoretical knowledge but still people doesn't understand how the real world operates. After university I felt like I knew everything, I knew Kotler backwards and forwards and all the theories..it felt like any way but when I started my first business (during my university years) I felt like I had to relearn everything. This lack of connection to reality was a problem for me and it is something I hear a lot for other business people. "Academics know nothing! ",one friend said and he has a Phd! Perhaps this illustrates the problem?
I guess it is the same in many fields..academia is seen as dry and not connected to the real world. What can be done about this or can anything be done? How do you view your education in relation to your working life? Do you feel your education was relevant? For me...not so much. Later I started to teach and do research but I still have this feeling. How do you feel about academia and the real world? Is academia part of the world we live in or just some "other place"..your thoughts?
Best wishes Henrik
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Well, I am not surprised that some outside academia may have difficult time recognising the value academia brings to improve our daily lives. I see two issues here. First, the academics might not have done a service by not interacting with practitioners to engage in research and teaching that is current. Second, academic institutions do not work towards creating awareness about the important role they play for our society. Addressing these two might be a starting point.
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COVID-19 is changing the social life of all people. Jumping out of the personal aspect, how does it affect the family as a whole.
Family is regarded as the fundamental structure of the society, will COVID-19 changes the future family structure, unit and model?
How is it affecting gender issues too?
Besides, why is domestic violence increasing? Is psychology and psychiatry playing a role?
reference:
[1] Campbell AM. An increasing risk of family violence during the Covid-19 pandemic: Strengthening community collaborations to save lives.
Forensic Science International: Reports vol. 2 (2020): 100089.
[2]COVID-19: Reducing the risk of infection might increase the risk of intimate partner violence
EClinicalMedicine
[3]The pandemic paradox: The consequences of COVID‐19 on domestic violence
J Clin Nurs
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Effect of lockdown is domestic violence increasing day by day.
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Many studies and analyes we do require statistics to back up. However, many times the results run out to be statistically significant, yet when interpret it in the clinical context, it is too small to be significant.
This is rather frustrating. Any solution for solving this?
Is those very small interval unit scale more easily affected?
Can we change our analytics method to cope with the results?
Beyond statistical significance: clinical interpretation of rehabilitation research literature.
Int J Sports Phys Ther. 2014;9(5):726–736.
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Good question
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I understand vaguely that the first author is supposed to be the one who "did the most work", but what counts as "work" in this comparison? Does "most" mean "more than all the other coauthors together" or just "more than any other coauthor"? What happens when the comparison is unclear? How often is "did the most work" the actual truth, versus a cover story for a more complex political decision?
I realize that the precise answer is different for every paper. I'm looking for general guidelines for how an outsider (like me) should interpret first authorship in your field. Pointers to guidelines from journals or professional societies would be especially helpful.
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As the contributions in this thread are documenting, there are obviously some highly emotional aspects concerning author's lists...
In my field, typically the first author is the one who did most of the work and I never really understood the discussions about the ranking after place 1. I am always happy if everyone is included who contributed with anything and alphabetical order is ok for me.
The world would probably better if we could put away our vanity more often.
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How to remove toxic heavy metal traces like mercury, lead, cadmium etc. from solid herbal material or food material?
is there any specific methodology or technique to remove metal traces from solid material like food or plant herbal material?
so that after removal of metal, the solid material can be used as food or medicine.
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For the good quality medicinal herbal products the quality of initial raw herbs is an important aspect, and it starts from Good Agricultural Cultivation Practices (GACP) to Good Herbal collection and processing practices. If we are cultivating the plants in a good quality soil and clean environment and if adopting proper collection, processing and storage conditions then the quality raw material will be produced and ultimately it prevents contamination from heavy metals and toxic substances.
Before the use of these herbs in medicinal preparation their physico-chemical analysis will confirm their standards and substandard material containing heavy metals/toxic materials can be rejected.
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Are immunity enhancer medicine (Homeopathic and Ayurvedic ) helpful to prevent yourself from Corona virus?
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AYUSH Remedies - Approved by Govt of India to fight against Covid19 - The basic
concept is to boost up the immunity - http://www.fondpageant.com/deref/https%3A%2F%2Fwww.mohfw.gov.in%2Fpdf%2FImmunityBoostingAYUSHAdvisory.pdf - as advised by Ministry of Home Affairs ( MoHFW ) , India .
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In a paper deposited in BioRxiv entitled: "Susceptibility of ferrets, cats, dogs, and different domestic animals to SARS-coronavirus-2" the team from Harbin Vet Institute intentionally infected several species of animals including cats with SARS-CoV-2. The results showed that the virus was transmitted between the cats, but no sympthoms of COVID-19 were observed.
This result is interesting in terms of an observation made by a medic from Spain - Sabina Olex-Condor that from the 100 patients serious with COVID-19 that she examined there were no cat owners. She suggested as a hypothesis that due to cross-immunity (cats are a known reservoir of coronaviruses) cat owners have milder sympthoms of COVID-19.
I'm aware that the paper from Harbin Institute is a pilot study, has many possible dead ends and limitations. I'm also aware that this cross-immunity hypothesis suggested by Sabina need serious assement due to limited number (and problalbly non-representative set) of patients.
Do you think that this is possible in terms of knowledge of human immunology? If the above is met do any of you have access to indepth demografic (?) data of people infected with SARS-CoV-2 to check this hypothesis?
Disclaimer: not an expert in medicine or veterinary, I study plant genomics, this is pure scientific curiosity.
I hope that your families and friends are well.
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Various medical institutes are making their efforts in preparation of vaccine for Covid-19 disease. The medical trials are lengthy in process, how much time it will take for fullproof vaccine for the disease. Please express your views. Thanks
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Ravindra S Bankar "The medical trials are lengthy in process..." The trials are extremely, and, under normal circumstances, irresponsibly short! By the way, most vaccines fail in phase III trials.
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The literature regarding gender and the distribution of personality traits ( Big five personality traits model as a reference,; McCrae & Costa) are pretty clear. Women score higher on traits such as agreeableness and openness for example. There are some examples in the literature regarding why there is a difference between men and women in terms of personality traits. However how does sociological factors such as the influence asserted by the individuals belonging to social group, ethnic group, culture etc. Can we say that women across the spectrum are more agreeable or open and men are less agreeable according the the big five personality traits model (McCrae & Costa 1985 etc) or are there other markers that also influence out traits...can it be that in some cultures women are less agreeable than men for example or do you think the big five model and the distribution of traits in terms of a gender perspective is universal? Are there any identifiable research gaps in your view? Best wishes Henrik
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Universal peronality traits for female and/or male actors do not exist.
However, we can observe female and male energy flows
(strong alternating current vs. direct current).
For 'Western' psychology, the earth is still flat.
While there are great cultural differences of personlity traits, we can observe fundamental interactive energies of male and female as general principles of human thermodynamics.
German writer Goethe was early to point to ellective affinities
as foundational behavioral principles of men and women.
You have pointed to an important research topic, which is still in its infancy, concerning sound scientific analysis and practice.
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I'm working on making new compound medicine, but I don't know how to evaluate the chemical interaction in lab environment (cristalization and other interactions) please help me. If you know a book or article can help me, I will be so grateful.
Thanks
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A change of subject a new way to look at small things!
The new normal----wear a snug fitting cotton mask-----and, because no mask is 100% effective----upon removal of the mask,---sanitize your saliva with a mouthwash that contains 1/2 % hydrogen peroxide.
See attachments
Don
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There are two theories that are quite similar in nature, but different in substance, The theory of Mind and the theory of Mentaliz(S)ation, sorry, Im allergic to American spelling...pls dont kill me now :-) My understanding of them is this "Both of these concepts, mentalization and the theory of mind, describes processes that are metacognitive in their nature . Mentalization mainly concerns the reflection of affective or emotional mental states. In contrast however the, theory of mind focuses on things epistemic in nature such as beliefs, intentions and persuasions. My idea is that these two theories by them self are incomplete but combining elements of both, gives us a clearer understanding. Cognition and affect can't in my view be separated, they are both part of us as human beings and also a part of other animals. What are your thoughts? Am I wrong or right? I can stand criticism so bring it on...
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Dear Nicolás:
Yes, I think your distinction intriguing. I wonder what would constitute "new findings"? This is what I wrote about it in my field:
As a subcategory of aesthetic cognition, poetic cognition has the potential to provide a theory and methodology in establishing the nature of poetic effects and relating them to human cognitive processes. However, like all interdisciplinary endeavors that attempt transdisciplinarity in their applications, “where both disciplines are borrowing and lending” (Callies et al. 2011: 3), such research is still in its very early stages. Simon Penny (2017: 427-433) notes that interdisciplinarity is inherently unstable. It comes into existence as new world views begin to emerge, and moves toward the formation of a new discipline. It is characterized by the temporary adoption of terminology from concepts developed in various disciplines, terminology which inevitably loses the rigor of its original formulation as it embraces phenomena from environments different from those in which it was first employed. During this stage, meanings themselves become unstable, a condition which marks Penny’s (2014) first stage in the life history of a discipline:
1. the stage of half-formed vocabulary and vague promises;
2. the stage in which ideas from various fields are interfaced, and new relationships and distinctions are built, out of which, assiduously and incisively, a new vocabulary, reflective of a new world view, is built;
3. the stage when this vocabulary is deployed by members of the group in order to conduct sophisticated and dense discourse(s). In this stage the epistemological history of these terms is shared knowledge and the terms operate as shorthand;
4. these terms, rather than standing for a history of research and debate become reified, and, for instance, are written about in textbooks and taught, to a new generation of students who take these ideas as axiomatic ground-level realities. As a result, terminology so rigorously developed in 2+3 become like magical incantations full of presumed meaning;
5. the stage of paradigmatic failure, where problems arise which often appear to need, i.e., only technical or methodological tweaks, but as problems progress, turn out to be problems in principle. The explanatory power of the paradigm comes into question and interrogation, internal and external begins. Return to 1 and repeat.
Penny’s stages are not quite so rigidly defined as a discipline develops in actual practice, when traces characteristic of different stages may occur at the same time. Nevertheless, Penny’s stages are helpful in providing a rough outline of the life cycle of a discipline.
Apologies for the length. Margaret
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Empirical use of non-harmful drugs for patients is superior to evidence-based medicine ... or not
Does anyone use famotidine in COVID?
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I should probably also add that in addition to the increased risk for COVID-19 infections, using the drugs may increase the risk of other gastrointestinal infections for other pathogens. This would increase overall pathology as well as risk for any of these infections. Nutritional damage and other effects may also occur, even if not severe.
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I am starting a systemic review. And it's my first one. I have figured out the PICO and search keywords. I am overwhelming with massive results from different search engine. They contains duplicates. What is the best practice to combine all the result and remove duplicates.
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There are various tools such as EndNote, RefWorks, Mendeley, Rayyan, Zotero, Covidence and others. Covidence is a good option for undertaking Cochrane systematic reviews, but it is not free to use. Covidence is free for those authoring the Cochrane reviews.
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Can we use artificial intelligence technologies such as Machine Learning and Deep Learning to help in finding medicine or vaccine for COVID-19. Any ideas?
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Yes! Please see the RG link below.
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What are the most important factors to considered when thinking about the cities of the future? What scholars to involve? Or, can we even leave some academic discipline behind and not include them in discussion?
This is just a teaser for an upcoming conference...
Theology in Rijeka and the Department of Philosophy of the Catholic Faculty of Theology at the University of Zagreb, the Department of Social and Human Sciences in Medicine at the Faculty of Medicine of the University of Rijeka, the Faculty of Health Studies of the University of Rijeka and Faculty of Theology at University Nicolaus Copernicus, Toruń (Poland) - organize an international symposium, titled ?The City of Future: Anxiety of Expansion“, which will be held on November 13, 2020 (Friday) in the Theology Building (Rijeka, Omladinska 14).
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One of the most important factors to ensure world peace is for city governments to prioritize good planning for the future, including conducting many scientific studies and investigations to determine short-term objectives and long-range goals.
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The situation is going worse and the health system in IRAQ is so poor to provide the simplest treatment needs of patients. What should we do in such a horrible situation?
Is there advice that should we follow to stay safe and healthy until they come up with the vaccine of COVID-19.
How to make our immunity stronger in this situation, what should we eat? what should we drink? what kind of medicine should we have to have at 顺心彩票?
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I am interested in how people and cultures view practitioners and supporters of Nutraceuticals. For generations, food or plant based substances have been used as a treatment for disease. The pharmaceutical industry has replaced grandma remedies. Charlatans have given the herbal drug industry a bad name. True believers of herbal cures though have also stretched the public's faith with cures for baldness to cancer and now to Covid-19.
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Thank you for your thoughtful answer. There is so much to learn and it is so easy to scoff at that which we do not understand. Continued success with your mission.
brigid
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How weather can be a factor in Corona virus spreading? As Africa is still safe from it.
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Under COVID-19, healthcare facilities requests a lot of sterilization to prevent hospital transmission of the disease. Bleach solution and many other disinfection agents may not be effective against such a large scale of usage.
Can ultraviolet light be used to inactivate the virus?
Can it be applied on whole room disinfection?
Can it be used on high turnover medical equipment sterilization? E.g. stethoscope.
Can it be used to inactivate infected donors' blood products or body fluids?
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Please take a look at this useful link for insights.
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What are different coil shapes used in Transcranial Magnetic Stimulation? What are their differences (in induced current)? Do they have different applications?
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Dear Nezad,
Actually, among standard commercial coils, the double cone coil offers high energy efficiency and balance between stimulated volume and superficial field strength. Direct TMS of targets at depths of approx 4 cm or more results in superficial stimulation strength that exceeds the upper limit in current rTMS safety guidelines. Approaching depths of approx 6 cm is almost certainly unsafe considering the excessive superficial stimulation strength and activated brain volume. Couple of effects might have seen with choice of shape/size/dimension/ material listed below.
Effect of coil shape/size
(1) ****Smaller coils have a focality advantage over larger coils; however, this advantage diminishes with increasing target depth. Smaller coils have the disadvantage of producing stronger field in the superficial cortex and requiring more energy.
(2) When the coil dimensions are large relative to the head size, the electric field decay in depth becomes linear, indicating that, at best, the electric field attenuation is directly proportional to the depth of the target.
(3) Ferromagnetic cores improve electrical efficiency for targeting superficial brain areas; however magnetic saturation reduces the effectiveness of the core for deeper targets, especially for highly focal coils. Distancing winding segments from the head, as in the H1 coil, increases the required stimulation energy.
Ashish
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I am interested in how people/cultures view specific foods as cures or treatments for illnesses.
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Yes! of course.
"Let food be your medicine & medicine be your food" (Hippocrates).
A good herbal diet (herbal remedies) is a winning combination of an effective approach to optimal health and the answer to health, health care and medical happiness.
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Hello Colleagues
Recentrly, fungal infections cause an increase of morbidity and mortality in hospitalized patients and in immunocompromised persons. What are the most recent recommendations and guidelines for the control and prevention of nosocomial fungal infections.
Thanks
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The last two decades have shown an increase incidence of nosocomial fungal infections in hospital environment.The important fungi that are implicated in nosocomial infections are Candida albicans, Non-Candida albicans, Aspergillus fumigatus and Non-Aspergillus fumigatus, Fusarium species and others. We have isolated several fungal pathogens from burn wounds of patients admitted in burn ward of the hospital. Certain measures, such as personal protective wear, proper hand hygiene, respiratory hygiene, thorough cleaning and disinfection, safe injection practice, avoidance of sharp needle and scalpel injury, and waste disposal besides prompt medical attention to skin injury, and appropriate treatment with anti-fungal drugs (fluconazole, itraconazole, Amphotericin B, posaconazole etc) can be effective to prevent nosocomial mycoses.
One see the following paper on nosocomial mycotic infections.
Alangaden GJ. Nosocomial Fungal Infections: Epidemiology, Infection Control, and Prevention. Infectious Disease Clinics of North America 2011;25:201-25.
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Hi everyone! I got an invitation to submit a paper to the following SCI-E/SCOPUS MDPI journal (special issue):
The Article Processing Charge (APC) is 1400 CHF (Swiss Francs) per accepted paper. However, the fees will be fully waived (as it is an invitation to contribute) if I can submit the paper by the end of June 2020.
If anyone have a collaboration idea, please send me a message.
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Hello, we can work on neuroimaging analysis using ML/DL, I am specialized in neuroscience and you can contribute to the ML/DL application. If you are interested, email me at weixi20kang@gmail.com. Thanks.
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Hi all,
I am stuck at the following problem: I need to determine if there is a significant difference in Length of stay (LOS) in two groups: decendents and survivors, in different age groups. Can somebody help me with this? In a similar article I found they did use kruskal wallis to calculate this. Somebody some ideas to solve this in stata?
Thanks a lot!
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Hello Daniel,
The two independent variables (age group: 3 levels; and type of case: 2 levels) could be evaluated in a two-way anova design. If there is any concern about conformance to normality and/or homogeneity assumptions, then exact/resampling/bootstrap estimation may be used to derive the significance tests. These are increasingly available within or as adjuncts to many statistical software packages and libraries (e.g., R, SPSS, SAS).
Here's a couple of links that you may find helpful in this regard:
Good luck with your work.
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Consider the following voluntary scheme. There would be some eligibility requirements that would be consistent with the principles of health promotion. Only certain target groups would qualify.
You sign up and for walking 10,000 steps per day, you get a certain amount of money deposited directly to your cell phone. In principle, and in theory, what is wrong with this? In practice, people could cheat and so on but with the development of new technologies, it would be much more difficult to cheat so this disadvantage can be minimized. The funds for this scheme could come from a public-private partnership.
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Joseph Tham this is a great question and I applaud your efforts to plumb the ethical dimensions. I wonder if the responses would be equally well-received if it was inverted asking pretty much the same thing. " Would it be ethically acceptable to decline monetary incentives to those not reporting sanctioned health behaviors, such as daily walks?
Interesting as this scheme sounds similar to other health care and insurance company incentives. If I go for yearly check-ups, wellness visits etc., I receive a $500 dollar reduction on my health care premiums. Of course, I engage in this behavior because of the "incentive". But it could be equally be seen as punitive if I don't engage in these behaviors. It is designed so that my behaviors are not private. Sanctioned behavior becomes one of the public (or at least medical) records to be used in whatever fashion is deemed appropriate by whoever has access.
There are many ways these could be decoupled. They could have other parties that monitor the behavior and provide the incentive from stakeholders without telling the stakeholders who is receiving the benefit. Separating the validation from the medical and insurance records would encourage behavior while preserving privacy. But I suspect this, like so many other things, is not about promoting positive behavior as it is about mitigating risk and the affiliated cost of private information. So, while it is a blunt tool, it may be the best one available to all involved.
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People around the media are discussing the usage of facemask under COVID-19. ANd many evidence are available, yet no definite conclusion.
I have just gone through this study
Effectiveness of Surgical and Cotton Masks in Blocking SARS–CoV-2: A Controlled Comparison in 4 Patients
Ann Intern Med. 2020.
DOI: 10.7326/M20-1342
What do you think?
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This is my report about RG's deplatforming of my article " Masks Don’t Work: A review of science relevant to COVID-19 social policy", after it reached 400 K reads on RG. My report has the exact email exchange, which clarifies the reasons given for the censorship: https://archive.org/details/covid-censorship-at-research-gate-2/
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Under the pandemic of COVID-19, screening becomes important to tackle the spread. Fever is one of the screening criteria for many public places screening for access.
However, how is fever defined?
Is the 0.1 degree change makes the significance?
What is the range of standard deviation being acceptable?
What machine is accurate?
Is those hand held infrared measuring machines reliable?
Is there scenarios giving false negative tha may make a huge consequence?
Normal Body Temperature: A Systematic Review.
Open Forum Infect Dis. 2019;6(4):ofz032. Published 2019 Apr 9.
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Following
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aoa i have undergone analysis of differents researches if we reduced its reproduction by preventing pcr activity
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try to understand questions
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This might be considered a worst case scenario.
Repeated strikes by such a virus would scythe defenseless new victims each time, leaving fewer and fewer survivors.
For the species to survive, humanity would have to evolve resistance or other means of survival.
Is such a virus possible?
How would its epidemic spread be modeled?
Has a virus like that occurred in the past?
How would we deal with such a virus in the future?
What strategies would defeat such a virus?
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In the absence of acquired immunity and/or effective vaccine against viral infection, breaking the chain of infection becomes the only option. Moreover some individuals possess innate resistance to some infections. This group of individuals will be protected even without acquired immunity and help to protected others through Herd immunity.
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It obvious that use of expired medicines where there are alternatives is unacceptable. There are, however, situations where the only available alternative medical product (medicine) used for life-threatening disease condition is expired and left with bare hands. What do healthcare professionals do on this situation, especially in this covid-19 pandemic where procurement is a challenge? Based on the risks-benefits assessment - the risk of leaving a patient without alternative and using expired medicine to save the patient and its associated risks - if they clinicians are going to use the product, what strategies they should follow to avoid medico-legal issues and transparency with consumers.
Looking forward to hear back from you?
Kind regards,
Mulugeta
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Many products have an extended shelf life. Most people would use an expired EPI pen in an emergency situation if that was all that was available. On 05 Feb 2020, Medscape published an interesting article by Douglas Paauw, MD, "Are Drug Expiration Dates a Myth?" https://www.medscape.com/viewarticle/924683_1
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Genome sequencing helps find vital information, for example the strain type, virulence, location of origin and differences between strains transmitted within the country and in other countries
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You can find a centralized database of genomes on https://www.gisaid.org/ . To access them, you have to register and it can take some time to actually obtain the info. Nevertheless, you can see the authors of the publications and contact them directly.
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I need two mammography datasets sourced by different counties or institutions where images are similar to each other.
I'm reading the International evaluation of an AI system for breast cancer screening released by google Jan-2020
They used two datasets. One from the UK (OPTIMAM) which needs permission for use. The other from Northwestern Medicine which again needs permission to use.
Are there publicly available datasets that resemble the two above mentioned datasets? especially the OPTIMAM?
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Dear Brian Formento,
-I would suggest you to try with MIAS dataset using following web addresses:
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Can anybody help me to find out such website where i can find out solubility of any drug or medicine at one place?
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drugbank.com, pubchem
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FDA has issued guidance to provide recommendations to health care providers and investigators on the administration and study of investigational convalescent plasma collected from individuals who have recovered from COVID-19 (COVID-19 convalescent plasma) during the public health emergency.
The guidance provides recommendations on the following:
  • pathways for use of investigational COVID-19 convalescent plasma
  • patient eligibility
  • collection of COVID-19 convalescent plasma, including donor eligibility and donor qualifications
  • labeling, and
  • record keeping
Because COVID-19 convalescent plasma has not yet been approved for use by FDA, it is regulated as an investigational product.? A health care provider must participate in one of the pathways described below.? FDA does not collect COVID-19 convalescent plasma or provide COVID-19 convalescent plasma.? Health care providers or acute care facilities should instead obtain COVID-19 convalescent plasma from an FDA-registered blood establishment.
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what should be the ratio of sodium benzoate in preparing a herbal suspension ?
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What is pH of the herbal suspension?
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Dear Colleaugues,
There was a proposal of a researcher who asked me to write down a paper which will more or less extend the poster (link bellow) published at ICCB 2016 in Prague. This all happened by an accident. I did not like to come at a conference without some presentation. Hence, I did quickly put the ideas that are resonating in my head for years on that poster to allow other researchers to benefit from it. Surprisingly, this poster is getting a great deal of attention. Therefore, I am thinking about to write down a review (prescription) how to design sel-organizing and emergennt systems with a rich example aparatus. If you like the idea then wisit the poster and let there a comment about it (bellow the poster).
The whole project is meant as a service to the community of biological and medical researchers who would like to know more but have no time to study mathematics and programming in depth.
All the best at your research,
Jiri
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Emergence phenomena is a kind of phenomena observed in a lot kind of systems (from arts to philosophy, biology, physics and so on). Emergence theory is the formal approach to study those phenomena. It is a very exiting area!
Actually, as you probably know, there are different levels of emergence. You may have weak emergence, strong emergence or even some intermediary relations. The kind of emergence phenomena you are considering are of weak type, which are typically related with complex systems (as maybe you were keeping in mind when you said (...) understand the dynamics of organizations' emergent properties that are virtually impossible to resolve by using any other mathematical tool (...).
I note, however, that a system A which weak emerge from a system B can a priori strongly emerges from a system C which itself strongly emerges from B (there is no contradiction because the emergence relation is not transitive in the general setup). This means that one can try to understand weak emergence relations (and therefore those complex systems) indirectly by looking at strong emerge relations.
With this in our minds, a natural question is the following:
  • existence problem for strong emergence. Given two systems A and B, can we find some strong emergence relation between them?
At present I'm very interested in studying this problem for physical systems, but a priori the methods could be generalized to other kind of systems. I've a recent work on the subject:
It is part of project:
You can also see a post in my blog and in Medium about Emergence Theory:
Good luck with your work.
Best,
Yuri.
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As we know that, every country will take a standard time to the approved patent of medicine, however in this pandemic situation, this will continue in the same process? Should we not consider the situational gravity for the greater good of humanity?
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Considering the seriousness of the current COVID-19, the agency authorized to issue patent, is advised to give patent to drug as early as possible so that the drug can be used to treat the COVID-19 patients.Early patenting of drug will certainly help to save the life of patients.
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I was working for a project. The computational part is done. Now it's time to write a paper. But I am procrastinating much and actually I am not sure how to start or where to start.Which part should I write first? How can I accelerate the process.
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Start with the materials and methods because you have already completed this part
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Is it fair and reasonable to say that in the medical sciences, English is widely accepted (universally?) by scientists as the main language for communication and defending research findings?
At this point in time, is this a valid statement?
Will this acceptance continue in the foreseeable future?
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Yes, it is used in many countries and most people understand.
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Conozco algunos centros comunitarios que trabajan con este tipo de medicina, y considero que parte de la sabiduría en ciencias de la salud parte de como se tratan las enfermedades actualmente en las comunidades de los pueblos nativos.
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Si, la mejor forma que tienes para desarrollarlo es siguiendo procedimientos acercados a los desarrollos farmacéuticos. Trabajar con ensayos clínicos a fin de testear la eficacia y seguridad de los insumos tradicionales
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Academic journals publish original articles and higher level of evidence like review as their basis of survival. However, most journals also allow the manuscript type of "Letter to the editor" for readers in the field to reply previously published articles or on special events and issues like those once in a lifetime e.g. COVID-19.
As a researcher or author, do you think it is worth writing such a manuscript type?
Can you resubmit such "Letter" to another journal I'd being rejected?
Will you expect any citations from such "Letter"?
Will such "Letter" be externally peer-reviewed?
Is an underlying relationship with the editor an advantage of writing such "Letter"?
What do the editor expect you to write before accept your "Letter"?
Will "Letter" increase your h-index number?
There is no source of information on the acceptance rate of such articles.
Do you have any experience on the acceptance rate of such?
If such "Letter" is rejected, how will you handle the hard work with great effort paid?
How to write a letter to the editor that the editor will want to publish.
Can Med Assoc J. 1985;132(12):1344.
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As a researcher or author, do you think it is worth writing such a manuscript type?
Yes - especially to raise points of debate. A letter to the Editor can effectively be a form of 'post-publication peer review'
Can you resubmit such "Letter" to another journal I'd being rejected?
Yes
Will you expect any citations from such "Letter"?
Yes, in my experience
Will such "Letter" be externally peer-reviewed?
This is at the discretion of the Editor
Is an underlying relationship with the editor an advantage of writing such "Letter"?
It should not be
What do the editor expect you to write before accept your "Letter"?
Your letter should contribute intellectual value
Will "Letter" increase your h-index number?
A letter does not usually represent original research so not usually.
There is no source of information on the acceptance rate of such articles.
Do you have any experience on the acceptance rate of such?
Yes - it is easier to publish a letter to the editor compared to an original research paper. They take up less space in the journal
If such "Letter" is rejected, how will you handle the hard work with great effort paid?
Rejections are common throughout academic publishing. Take on board feedback from reviewers/senior colleagues and keep trying.
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What does it even mean? Are you suffering from Empathy Deficit Disorder (EDD)?
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Lack of concern and care for others. GED is a big word and encompasses many dimensions which is not easy to measure. Like all latent variable and concepts we need to test for validity and reliability before we can be sure of what we are measuring.
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In the age of Covid19, is there a basic conflict between science and superstition in the discipline of medical knowledge? Are there some simple, sensible, robust and reasonable ways to distinguish a scientific statement (or fact) from a superstitious statement?
To stay focused, the topic will concentrate on science versus superstition in the scientific discipline of medicine. We will try our very best to stay focused and not stray off track. it is very easy to wander off message and be all over the map. i will try to summarize the key conclusions from time to time.
In the age of the Corona Virus, there are so many statements out there. The statements may not be scientific. But if they are not scientific, are they false? Are they fake? Are they simply statements based on superstition.
What should we do if people believe in statements that are not based on science? Should we be polite and tolerate their beliefs?
As long as people do not harm others, then from society’s point of view, the fact that people hold non-scientific hypotheses is probably benign. However, the trouble starts when the same people act these beliefs, and then cause harm to others. The question arises: what should society do in this case?
Based on the discussion, there are two assumptions and four categories.
Assumption1: Beliefs cannot be justified or unjustified.
Assumption2: hypotheses can be disproven
Scientific hypotheses that are based on justified facts in natural causation. Or scientific hypotheses have not been disproven (I prefer the negative formulation because we may never be able to prove anything but we are unable to disprove it.)
Since science cannot give a definitive answer, there are many competing answers that merit our attention, and we may not be able to select among them.
Non-scientific hypotheses are unjustified facts that may be “proven” in the future with better evidence and facts.
Pseudo-scientific hypotheses: not sure where these fit in?
Superstitions are unjustified beliefs in supernatural causation.
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Joseph Tham, thanks for a thought provoking question. I think we should tolerate and respect beliefs and ideas that are not considered scientific. Our intolerance of such beliefs and ideas could be the result of a lack of understanding of the science behind them. We should therefore subject them to rigorous testing using the scientific method. A practical example is the fact that the World Health Organization has not dismissed out of hand the herbal remedy from Madagascar that is claimed to prevent illness from COVID-19. Instead the remedy is going to be tested using established scientific principles. The null hypothesis can then be rejected or accepted. This is how Indigenous Knowledge Systems contribute to scientific advancement.
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WEIRD (Western, Educated, Industrious, Rich, Democratic)
Typically, WEIRD people have Western-influenced education. They are comfortable in international languages and have non-traditional values. Usually, they are young, hardworking, urban professionals with living and working experiences abroad.
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It is not easy for someone from outside the culture and education to integrate into the society, what more to offer advice to policy makers. This happened even to East Asian countries where the influencial policy makers are 顺心彩票 grown.
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What are the merits, if any, in the challenges that lawyers and economists have raised against the Covid19 lockdown? How much weight should society give to the opinions of epidemiologists?
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Your excellent questions might be complemented by several additional ones: who is behind the epidemiologists? Who is financing them? Which are the real interests of the research funders? These questions are not related to conspiracy theories but to the Covid-19 reality. Cui bono the lockdowns? Who is paying for the side-effects due to lockdowns? What about those people who could not be operated on time and lost their lives because their operations were cancelled? Nobody is counting the collateral victims. Why? We know by heart Covid-19 statistics. Pandemic is the omnipresent topic everywhere. What about the vital questions of humanity? Have they just disappeared?
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In a patient with hereditary desminopathy (Thr341Pro DES mutation in a heterozygous state) with disease progression, a significant decrease in olfaction is noted. How can this fact be explained?
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I agree with Japneet Kaur. The problem in the cilia of olfactory sensory neurons. The myofibrilar myopathy is a genetic disease that associated with the primary ciliary dyskinesia. The primary ciliary dyskinesia resulted in defective cilia and olfactory receptors.
Attached, please find the article describing both myofibrilar myopathy and primary ciliary dyskinesia.
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Some reports suggest that in the fight against Covid19, the use of ventilators have not saved lives. How do we assess these reports? Any merits?
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Ventilators are helpful in palliative medical care for some COVID-19 patients, but not all; therefore, ventilators should be made readily available even though only a fraction of patients will need them.
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Hi,
I am conducting a research project to see whether demographic/patient factors can predict patients who are likely to suffer a post-operative death (Categorical outcome Y/N).
I have conducted univariate regression procedure using SPSS Firths regression as I have a small sample size with the dependant variable being a sparse event. This has given me 3-4 variables with P<0.10.
DO I now proceed to perform a multi-logistic regression? If so, do I run Firths regression with all of these variables selected as co-variates or do I perform a more traditional multi-nominal regression model instead?
Any help would be appreciated as I can't find any guidance on this issue.
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Dear Suliman Ahmad,
Hi,
In order to graphically categorizing data, SPSS software does not have enough accuracy in graphical classification because it performs the classification operation with a linear criterion, not a point. Therefore, the results of the outcome from group classification are not accurate enough. This software is very suitable for statistical analysis.
Other software such as NTSYS-pc, PAST, PC-ord, CANOCO, TWINSPAN, Mathlab and etc are recommended for this.
Best,
Saeed
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COVID-19 has pull people apart from each other. Social distancing is the main way to prevent spreading of infection. Tele-medicine, once used for rural area remote healthcare model, is the emerging new way of practice under COVID-19.
Different specialties have different practicing needs, what difficulties do you encounter on applying tele-medicine under COVID-19 in your specialty? Will tele-medicine totally uproot the usual face-to-face room consultation of medical practitioners? And becoming the new service model?
What is your view?
Some references:
Virtually Perfect? Telemedicine for Covid-19
NEJM
DOI: 10.1056/NEJMp2003539
Covid-19 and Health Care’s Digital Revolution
NEJM
DOI: 10.1056/NEJMp2005835
Telemedicine in the Era of COVID-19
The Journal of Allergy and Clinical Immunology: In Practice
DOI: 10.1016/j.jaip.2020.03.008
Keep Calm and Log On: Telemedicine for COVID-19 Pandemic Response.
DOI: 10.12788/jhm.3419
‘Healing at a distance’—telemedicine and COVID-19
Public Money & Management
DOI: 10.1080/09540962.2020.1748855
The Role of Telehealth in Reducing the Mental Health Burden from COVID-19
Telemedicine and e-Health
DOI: 10.1089/tmj.2020.0068
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Hello, in Portugal, during Covid there was a huge increase of tele consultation. Still some barriers were found:
- older people have more difficulties in using digital tools.
- 3G and 4G coverage is still low in some rural areas.
- Lack of good tele consultation tools available to be used, some physicians then still want to do the face to face consultation.
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The World Health Organization (WHO) defines traditional medicine as "the sum total of the knowledge, skills, and practices based on the theories, beliefs, and experiences indigenous to different cultures, whether explicable or not, used in the maintenance of health as well as in the prevention, diagnosis, improvement or treatment of physical and mental illness". But some people believe traditional medicine is contrasted with scientific medicine.
What is your opinion? Can we use traditional medicine for treatment of COVID19? If your answer is yes, how do you want to do it?
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Please take a look at the following RG link.
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There are news on COVID-19 outbreak on ship, no matter cruise or military one.
And few aircraft carriers are also involved.
What is special about the ship arrangement that facilitated all these?
Nature 580, 18 (2020)
Limiting spread of COVID-19 from cruise ships - lessons to be learnt from Japan,
QJM: An International Journal of Medicine, , hcaa092,
COVID-19 outbreak on the Diamond Princess cruise ship: estimating the epidemic potential and effectiveness of public health countermeasures,
Journal of Travel Medicine, , taaa030,
Public Health Responses to COVID-19 Outbreaks on Cruise Ships — Worldwide, February–March 2020. MMWR Morb Mortal Wkly Rep 2020;69:347-352. DOI: http://dx.doi.org/10.15585/mmwr.mm6912e3
Estimating the asymptomatic proportion of coronavirus disease 2019 (COVID-19) cases on board the Diamond Princess cruise ship, Yokohama, Japan, 2020.
Euro Surveill. 2020;25(10):pii=2000180.
Chest CT Findings in Cases from the Cruise Ship “Diamond Princess” with Coronavirus Disease 2019 (COVID-19)
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Metal corpus of the ship (moisture, condensation, mold, lower temperature). Creates confined space.
Cold air currents when the ship is moving. Some cabins have a terrace. Other passangers use the common outside viewing decks.
Vibrations from the ship's engine disturb, days on end, the normal liquid environment (intracellular, extracellular) within which cells live, function, reproduce. The vestibular apparatus suffers as well.
Cleanliness - dubious. Could use the toilet brush to clean also the toilet seat and the sink with (as in many hotels around the world). Apparently, nothing wrong with that. :O
Lack of adequate ventilation (probably, the air conditioning system is linked between rooms at the same level).
Fresh water purity (absent - onboard water desalination; when were the filters last changed?).
Bacteria and viruses jump from sea water onto skin, in nose and throat via water droplets in the air. When humid, one inhales deeper. Boy, is this not helpful!
Toilets and shower waste water outlets connected - water pressure differential due to movement of the ship (esp. side to side). Splashes in the bathroom.
Rats, cockroaches, ants (need no introduction).
Goodness! What a long list, is not it?
Could be even longer.
Mitsubishi Heavy Industries should have some idea as to how long...
:)
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Describe impact of situation caused by pandemic of coronavirus COVID-19 on your Academic and Research activities.
Explain your action in a way to stay focused on Science and Preparing/Writhing/Publishing research.
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The gender gap: I do have to attend my child needs, specially related with the remote school activities plus cooking and cleaning the house. All these activities at the same time oh having a full time job as an specialist in higher education. Trying to get focus and reading for a while is such a goal!
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It's 99 days since the first case of COVID-19 in Hong Kong, and we are welcoming the 5th days of 0 new cases of COVID-19 following a week of <10 cases per day.
How should we define the end of a local endemic?
How long should the latent period be defined?
When is it safe to resume social activities?
Should territory wide screening of asymptomatic people be done before declaring the end of endemic?
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The summary of the bloomberg article spells it out. Herd immunity with its unfortunate 'collateral damage' as no one has any immunity to this novel pathogen, and secondly, immunization, which is still a long way off. Thus, prevention is better than cure, but there is no cure, except the above, besides for all the supportive treatment provided.
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A famine of food does not necessarily mean that there is a shortage of food; it is the inaccessibility of food. Is it the same with the Covid19, in the sense that there is inaccessibility to medical resources?
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No, because without medical supplies, Coronavirus would show its true nature and cause a natural maximum pandemic. The protective gear only serves to modify the different curves
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after the colonization of vibiro choleraea in intestinal of human being than cause diarrhea after secretion of cholera toxin. in serious case how can stop that secretion?
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Treatment and management of cholera are best accomplished by the administration of copious amounts of intravenous or oral fluids to replace fluids lost from the severe diarrhea. The administration of antimicrobial agent can be shorten the duration of diarrhea and thereby reduce fluid losses. However, resistance to tetracycline and doxycycline has been reported. Therefore administration of additional antimicrobials such as azithromycin and ciprofloxacin may be necessary.
SOURCE: Mahon book
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Developing a vaccine is an important task. What is the best way to achieve this goal? Should we use a global competitive process?
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Less than five months after the world first learnt about the new coronavirus causing fatal pneumonia in Wuhan, China, there are more than 90 vaccines for the virus at various stages of development, with more announced each week. At least six are already being tested for safety in people.
Now, developers, funders and other stakeholders are laying the groundwork for their biggest challenge yet: determining which vaccines actually work.
This typically involves giving thousands or tens of thousands of people a vaccine or placebo and seeing, over months or even years, whether there is a difference between the two groups in how many people get infected in the course of their daily lives, as well as checking that no safety issues emerge.
But in this pandemic, scientists will have to accelerate and streamline that process. A vaccine may be the only way to generate immunity to the virus across a population: despite the millions of coronavirus cases worldwide, some preliminary studies suggest that only a small fraction of people in even hard-hit regions have been infected with SARS-CoV-2, and their immunity is unclear.
This month, the World Health Organization (WHO) in Geneva, Switzerland, sketched out plans for a clinical trial that will test numerous vaccines in a single study. Some developers and funders have plans for their own efficacy trials. But key questions remain, such as which vaccines will be tested first — or at all — and how their effectiveness will be measured and compared.
“It’s going to require a level of coordination that has never really happened before, and a time frame that’s never really been even imagined,” says Mark Feinberg, president and chief executive of the International AIDS Vaccine Initiative (IAVI) in New York City. “You can’t take 200 vaccines into efficacy trials,” says Seth Berkley, chief executive of Gavi, the Vaccine Alliance in Geneva, which funds immunizations in low and middle-income countries.
Rolling trial
The WHO’s proposed Solidarity Vaccine Trial seeks to speed development with an adaptive design. This allows vaccines to be added to the trial on an ongoing basis. Participants will be enrolled continuously, and vaccines that don’t seem to be working can be dropped from testing.
The WHO still needs to hammer out details, such as how a vaccine’s efficacy will be measured, says Marie-Paule Kieny, research director at the French National Institute of Health and Medical Research in Paris. But she thinks its overall approach makes sense. “One of the challenges is prioritization — which vaccine should you test first,” she says.
The WHO has established an expert panel to prioritize vaccines for inclusion in its trial, but it is unlikely to be the only organization seeking to do this. “Some strategic alignment and coordination in this effort is going to be critically important or otherwise it'll become very chaotic,” says Feinberg. But the WHO plan “by itself may not be sufficient,” he adds.
The US National Institutes of Health (NIH) in Bethesda, Maryland, this month unveiled a partnership with more than a dozen companies that aims to coordinate the development of drugs and vaccines for coronavirus. And the Coalition of Epidemic Preparedness (CEPI), a global foundation that funds vaccine development, is supporting 9 different vaccines. The non-profit hopes to raise US$2 billion to pay for efficacy trials, manufacturing and other costs, says Melanie Saville, the organization’s director of vaccine research and development.
Criteria for prioritizing vaccines for efficacy could include its production capacity and the immune response generated in early human trials and animal studies, says Kieny, as well as regulators’ experience with the specific type of vaccine. Some of the kinds of vaccine being developed, such as RNA vaccines, have not been widely tested in people or used in a vaccine that has won regulatory approval.
A vaccine developed at the Jenner Institute at the University of Oxford, UK, is currently undergoing early-phase trials. “There’s a reasonable chance that we’ll be able to pick up the efficacy of the vaccine over the next couple of months,” Andrew Pollard, an infectious disease researcher at Oxford leading the trial, said at an online press briefing.
A small number of developers with plans and funding to get their vaccine approved and scale up production will likely call the shots with regard to how efficacy trials are done, says Rip Ballou, a program leader at IAVI. “Doing a phase III trial to show efficacy is meaningless if it's not coupled to a plan to actually licence and deliver under some regulatory authority,” he says. “There's only a handful of players that will be able to meet that very high bar. Because otherwise, it's a publication. It's not a vaccine.”
A fair shot
Another challenge will be determining how the different vaccines compare to one another. WHO’s proposal for an efficacy trial could allow the performance of different vaccines to be directly compared, but Kieny thinks that some developers may be unwilling to accept this because it could hurt a vaccine’s commercial prospects.
Swati Gupta, IAVI’s Vice President and Head of Emerging Infectious Diseases and Scientific Strategy, says vaccine developers will want to understand how key decisions are made before committing to trials that involve comparisons with other vaccines, to make sure their vaccines have “a fair shot at being able to show its efficacy”.
But it is essential to be able to compare different vaccines, even if it requires vaccines developers to set aside their short-term interests, says Charlie Weller, vaccine lead at the Wellcome Trust biomedical charity in London. “They work under commercial business models. That's not going to work for the situation we're in now," she says.
Expected global demand for a coronavirus vaccine could make developers more willing to cooperate. “We need more than one vaccine,” says Kieney. “Monopoly is always very bad, and none of the vaccines may have enough production capacity.”
One factor that could encourage such cooperation is the shifting geography of the pandemic. “China would have been a great place in Wuhan to have done efficacy trials two months ago,” says Berkley. “Italy would have would have been a great place to do it a month ago.” As a result, developers have incentive to join initiatives such as the WHO’s or the NIH’s, because of their access to clinical trial infrastructure around the world that could bring vaccines to where there are coronavirus cases. “We need to be nimble,” adds Gupta.
Emergency use
While most experts see large trials as a necessity to ensure that coronavirus vaccines are safe and effective, some developers are examining alternatives.
One option is to look for signs that a vaccine works in early-stage trials involving hundreds of participants, and then seek permission from regulators to deploy the vaccine under ‘emergency use’ rules in high-risk groups, such as health-care workers, who are more likely to be infected with the coronavirus. Regulators such as the US Food and Drug Administration can grant emergency use, while additional data is collected to license a vaccine.
Cansino Biologics in Tianjin, China, which is developing a vaccine comprised of a chemically inactivated form of SARS-CoV-2 virus, will consider this approach, according to a company spokesman. Johnson and Johnson said in a press release that its vaccine could be ready for emergency use in early 2021.
No vaccine has ever been deployed under emergency-use provisions, says Katherine O'Brien, who heads WHO's immunizations, vaccines, and biologicals department. If coronavirus vaccines follow that path, regulators will seek extra reassurance that a vaccine is safe. “There is no compromise that can be made on the safety issues,” O’Brien adds.
Momentum is building for an even more radical proposal to determine which vaccines work: intentionally infecting young, healthy volunteers, negating the need to wait for trial participants to become infected naturally. These ‘human challenge’ studies are already used to study infectious diseases such as malaria and dengue, and some researchers say they should be considered to speed the development of coronavirus vaccines.
Berkley says challenge trials could be used to rapidly determine which vaccines advance to large-scale trials. But he thinks they may be too risky without either an effective drug or a genetic test to identify the rare young individuals who are likely to develop severe disease. “Until you have a recognised treatment, I think that's a pretty tough story,” he says.
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Dear researchers
In your opinion, when is the peak number of cases of coronavirus disease (COVID-19)?
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When the virus becomes a reality for everyone to deal with as we deal with other viruses
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The virus is primarily spread between people during close contact, often via small droplets produced by coughing, sneezing, or talking. While these droplets are produced when breathing out, they usually fall to the ground or onto surfaces rather than remain in the air over long distances.People may also become infected by touching a contaminated surface and then touching their eyes, nose, or mouth. The virus can survive on surfaces for up to 72 hours. It is most contagious during the first three days after the onset of symptoms, although spread may be possible before symptoms appear and in later stages of the disease.
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by vaccination and finding the gens for the spike protein on the surface of corona virus and put them into a harmless virus to make a vaccine .. such technique if success, the pandemic virus will surely ended up .. but unfortunately .. it takes time
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Hello Everyone,
I am searching for journal whose impact factor is at least 1 and that do not have article processing fee for publication. I am looking for journal related to medicine or diabetes/endocrinology. Thank you.
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Take a look at Taylor and Francis Journals. There are some of them with free APC and no publishing charges.
E.g.,
Current Medical Research and Opinion [https://www.tandfonline.com/toc/icmo20/current ]
You can check if your affiliated institution has an agreement with any journals to publish open access at no cost to you:
All the best,
Monika
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Some people claim that the people that need the vaccine the most are the least able to pay for the vaccine. Is this a correct claim? If yes, what should be the appropriate policy response?
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Joseph Tham how are you? i would like to answer that yes, but the role of this COVID 10 pandemia during the last 4 months showed that not, underline because according with the human kind`s history: health, education, and human peace progress never being something really important for political leaders in opposite way the budget for supporting war in all sense always being the main aim of the rich countries developing or even poor countries.
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The evidence suggests that the Covid19 virus jumped from bats to humans.
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I agree with Dr. Sadanand Pandey
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As a public health measures to control the spread of the pandemic coronavirus, social distancing and 顺心彩票 quarantine are implemented in some countries.
As a matter of fact, patients are absence from clinic under COVID-19, and clinic-based diabetic control monitoring becomes challenging.
Do you expect a change in diabetic control for these patients when staying 顺心彩票?
They have less exercise, and may eat more snacks at 顺心彩票.
Or in contrast, they are too bored, and have time to develop new exercise without pressure from work? Besides, they are banned from social around, and may eat drink less alcohol and eat less feast.
What do you think?
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COVID-19 will increase vascular complications
Coronavirus associated with respiratory distress and ph changes Both Quarantine &Thinking increase stress hormones so more oxidations Limited Exercise will increase blood glucose level
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What are the latest updates about the route of transmission and its impact?
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Dear Dr. Ebada,
We know very little about COVID-19 at this moment and its effects on the developing and/or mature brain. In general viral infections can impair charnolophagy (CB autophagy) which is the basic molecular mechanism of intra-cellular detoxification (ICD) for normal function to remain healthy. By attacking the most sensitive neural progenitor cells in the brain, the virus can alter their pluripotency and induce charnolosome (CS) destabilization implicated in inflammasome (particularly NRLP-3) activation to induce hypercytokinemia and charnoptosis (CB apoptosis) implicated in pyroptosis, apoptosis, and necrosis of sensitive hippocampal and other CNS neurons by releasing Panx-1, Viroporine, and gasdermins to cause Charnoly Body Molecular Pathogenesis (CBMP) implicated in early morbidity and mortality through its general (Viral) lytic cycle.
For more details, you may please refer to my books " The Zika Virus Disease: Prevention and Cure" The Charnoly Body: A Novel Biomarker of Mitochondrial Bioenergetics" Fetal Alcohol Spectrum Disorder; and Nicotinism and Emerging Role of E-Cigarettes. I wish I could write more about it.
Dr. Ebada, It is all about Environmental Sanitation, our own Life-Style, Immunity, Mitochondrial Bio-energetics and intracellular detoxification through charnolophagy (CB autophagy), which is compromised by COVID-19 through CS destabilization to cause early morbidity and mortality by infecting the CNS. Thanks.
With Warm regards,
Sushil Sharma, Ph.D; D.M.R.I.T
Academic Dean
American International School of Medicine
Guyana, South America
.
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Have you ever imagined how the physically disabled people feel under COVID-19?
Which type of disability is most impacting these minority under COVID-19?
Autism? Cleft patients? Mental health patients? Deaf? Dumb? Blind? Loss of limbs?
How can we help them?
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Agree to Getabalew
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The image shows surgical and gynaecological instruments used by ancient Egyptians over 3000-5000 years BC. It explains how advanced medicine at that time, scalpels, forceps, curettes were known and what we use as surgical instruments date back to ancient Egyptians designs. The question is, do you have a history of medicine in your medical/health curricula? What are the objectives of this component? And how do you integrate this part to other elements in the curriculum?
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I agree with the answer of Dr. Om Prakash Sudrania .
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A milestone by Theodor Billroth in surgery and cancer surgery.
It is
- the 139th anniversary day (Jan 29, 1881)
Christian Albert Theodor Billroth (1829-1894)
performed
the first successful distal gastrectomy
for gastric cancer within 90 min
However, we may should be aware that everything in medicine surgery cancersurgery science needs teamwork
We are nothing without the Team!
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Theodor Billroth *26 Apr 1829 ?06 Feb 1894
Remembering giants in science, medicine and surgery - German Surgeon & Co-Founder of academic surgery
Happy Birthday
"I can not understand how someone can read receptively only"
"Only those who know the past & present of science and art, will boost their progress with awareness"
~ Theodor Billroth
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COVID-19 is spreading around the world, and faeces were popular and agreed for the presence of viral RNA with different studies reported. Its presence mean that the gastrointestinal (GI) tract is one of the hosting organ for such coronavirus.
How are other parts of the GI tract system affected by this virus?
Reference:
Clinical features of covid-19-related liver damage.
Clin Gastroenterol Hepatol. 2020 Apr 10.
Pancreatic injury patterns in patients with COVID-19 pneumonia.
Gastroenterology. 2020 Apr 01.
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Under COVID_19, most evidence and data are on adults, but more and more paediatric cases with some mortality are ongoing.
Let's gather all the paediatric related COVID-19 research here for referencing.
1) Yung CF, Kam K, Wong MS, et al. Environment and Personal Protective Equipment Tests for SARS-CoV-2 in the Isolation Room of an Infant With Infection. Ann Intern Med. 2020; [Epub ahead of print 1 April 2020]. doi: https://doi.org/10.7326/M20-0942
2) Brooks Samantha K, Smith Louise E, Webster Rebecca K, Weston Dale, Woodland Lisa, Hall Ian, Rubin G James. The impact of unplanned school closure on children’s social contact: rapid evidence review. Euro Surveill. 2020;25(13):pii=2000188. https://doi.org/10.2807/1560-7917.ES.2020.25.13.2000188
3) Dong L, Tian J, He S, et al. Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn. JAMA. Published online March 26, 2020. doi:10.1001/jama.2020.4621
4) Iqbal SN, Overcash R, Mokhtari N, Saeed H, Gold S, Auguste T, et al. An Uncomplicated Delivery in a Patient with Covid-19 in the United States. N Engl J Med. 2020 Apr 01.
DOI: 10.1056/NEJMc2007605
5) Qiu H, Wu J, Hong L, Luo Y, Song Q, Chen D. Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study. Lancet Infect Dis. 2020 Mar 25.
6) Zeng H, Xu C, Fan J, et al. Antibodies in Infants Born to Mothers With COVID-19 Pneumonia. JAMA. Published online March 26, 2020. doi:10.1001/jama.2020.4861
7) Zeng L, Xia S, Yuan W, et al. Neonatal Early-Onset Infection With SARS-CoV-2 in 33 Neonates Born to Mothers With COVID-19 in Wuhan, China. JAMA Pediatr. Published online March 26, 2020. doi:10.1001/jamapediatrics.2020.0878
8) Chen D, Yang H, Cao Y, Cheng W, Duan T, Fan C, et al. Expert consensus for managing pregnant women and neonates born to mothers with suspected or confirmed novel coronavirus (COVID-19) infection. Int J Gynaecol Obstet. 2020 Mar 20.
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I am interested in collaborating with any researcher working on modelling corona virus using fractional derivatives. If you are a researcher or you have a related project, please feel free to let me know if you need someone to collaborate with you on this research study. If you know someone else working on this research project, please share my collaboration interest with him.her. I would be very happy to collaborate on this research project with other researchers worldwide.
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Yes, I am working on such modelling for the COVID-19, and I am ready to cooperate with you in this hot topic.
Regards,
Emad
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COVID-19 is in no doubt affecting every walks of life. Its impact towards every one and others' psychological and psychiatric health is significant, yet how should we quantify them?
Let's pull all related publications here for reference:
Understanding and Addressing Sources of Anxiety Among Health Care Professionals During the COVID-19 Pandemic
The Mental Health Consequences of COVID-19 and Physical DistancingThe Need for Prevention and Early Intervention
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In my circle of friends there is a lively debate if corona is as dangerous as our media and governments is trying to portrait. Im one of those who doesn't believe Covid 19 is so much more dangerous to the general population than, lets say the flu. With that said I dont mean I would like to contract it, or any other illness. What is your take on the current situation? Is Covid 19 in your view something to be feared or do you like me view it as something that should not affect our lives and our economy to the extent it now has. How does your society handle the issue and what is your take? Best regards Henrik
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Novel coronavirus (SARS-CoV-2) is less fatal than SARS coronavirus (SARS-CoV) and MERS coronavirus (MERS-CoV) but it is highly contagious.
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COVID- 19
Respiratory infections can be transmitted through droplets of different sizes: when the droplet particles are >5-10 μm in diameter they are referred to as respiratory droplets, and when then are <5μm in diameter, they are referred to as droplet nuclei. According to current evidence, COVID-19 virus is primarily transmitted between people through respiratory droplets and contact routes.2-7 In an analysis of 75,465 COVID-19 cases in China, airborne transmission was not reported.
Droplet transmission occurs when a person is in in close contact (within 1 m) with someone who has respiratory symptoms (e.g., coughing or sneezing) and is therefore at risk of having his/her mucosae (mouth and nose) or conjunctiva (eyes) exposed to potentially infective respiratory droplets. Transmission may also occur through fomites in the immediate environment around the infected person. Therefore, transmission of the COVID-19 virus can occur by direct contact with infected people and indirect contact with surfaces in the immediate environment or with objects used on the infected person (e.g., stethoscope or thermometer).?
Airborne transmission is different from droplet transmission as it refers to the presence of microbes within droplet nuclei, which are generally considered to be particles <5μm in diameter, can remain in the air for long periods of time and be transmitted to others over distances greater than 1 m.?
In the context of COVID-19, airborne transmission may be possible in specific circumstances and settings in which procedures or support treatments that generate aerosols are performed; i.e., endotracheal intubation, bronchoscopy, open suctioning, administration of nebulized treatment, manual ventilation before intubation, turning the patient to the prone position, disconnecting the patient from the ventilator, non-invasive positive-pressure ventilation, tracheostomy, and cardiopulmonary resuscitation.?
There is some evidence that COVID-19 infection may lead to intestinal infection and be present in faeces. However, to date only one study has cultured the COVID-19 virus from a single stool specimen.? There have been no reports of faecal?oral transmission of the COVID-19 virus to date.
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Probiotics are live microorganisms that are intended to have health benefits when consumed or applied to the body. They can be found in yogurt and other fermented foods, dietary supplements, and beauty products.
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Under COVID-19, many human activities are suspended, public entertainment places are closed down. Football legends are almost fully cut off worldwide.
The targets for gambler to bet are less and less, no matter football, horse racing, boxing, bar ...
How do the psychiatric addictive gambler coping with their addiction under COVID-19?
In psychiatry, psycho therapy or behavioral modification is always used. Is COVID-19 helping these addictive gambler to run out of their obsession?
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In Hong Kong, currently popular legal physical (non-online) gambling would be horse-racing football and mark-six (a kind of lucky draw for numbers). Of course, there are many more different ones online.
However, the responsible organization (Hong Kong Jockey Club) closed down all the branches since COVID-19. There is a short period in between that it was re-opened, and many gamblers grasped the time to go in to refill or retrieval their accounts' money.
Unluckily, under social distancing rule, race course is banned for entry even for horse owners.
As a citizen, I can feel how broken hearts these horse racing gamblers are. And with time of few months, I feel that horse racing is falling out of colour.
Besides, football legends all over the world is closing as well. And bars for alcohol are all closed down by law too.
Of course, there is also Majong. Yet, shops providing these are also closed.
That's why I feel that people may shift their attention to others under COVID-19.
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Dengue fever is a disease caused by a family of viruses transmitted by infected mosquitoes. It is an acute illness of sudden onset that usually follows a benign course with symptoms such as headache, fever, exhaustion, severe muscle and joint pain, swollen lymph nodes (lymphadenopathy), and rash.
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A hospital-acquired infection (HAI), also known as a nosocomial infection, is an infection that is acquired in a hospital or other health care facility. To emphasize both hospital and nonhospital settings, it is sometimes instead called a health care–associated infection (HAI or HCAI).
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Please see the following RG link.
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COVID-19 is putting a huge impact on the society by the isolation measures it brings. People are now working from 顺心彩票 office, and every walks of life are pausing their usual work and life.
How about the booming exponential rise in COVID-19 researches? But a shut downed administrative team of the publishing office? And the loss of manpower towards battle over the. COVID-19 frontline?
With the limited journal space, will timely researches be delayed in publication? Which may miss out important messages towards the public!
Peer Review: Publishing in the time of COVID-19
DOI: 10.7554/eLife.57162
What's your view?
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Yes, I expect a delay in the publishing process under COVID-19.
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WHat do you think is the correlation? It's impact? and the possible transmission route?
Neurologic Features in Severe SARS-CoV-2 Infection
DOI: 10.1056/NEJMc2008597