S?ren Hofmayer

S?ren Hofmayer
ResearchGate | RG

12.09
?·?
Medical Doctor

About

38
Publications
367,323
Reads
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77
Citations
Introduction
Skills and Expertise
Cloning
PCR
DNA Sequencing
Cancer Biology
Molecular Biology
Genetics
Cell Culture
Molecular Genetics
Gene Expression
Sequencing
Show more
Research Experience
September 2018 - present
ResearchGate
  • Berlin, Germany
Position
  • CSO
May 2008 - August 2018
ResearchGate
  • null, Germany
Position
  • COO
April 2005 - August 2009
Medical School hannover
  • Institute of virology
  • null, Germany
Position
  • Adenovirus A31
Education
January 2006
Hannover, Germany
Field of study
  • SPSS
September 2004 - April 2006
Carl von Ossietzky Universit?t Oldenburg
Carl von Ossietzky Universit?t Oldenburg
Field of study
  • Economics
October 2002 - December 2008
Hannover Medical School
Hannover Medical School
Field of study
  • Medicine

Publications

Publications (38)
Table 1 : HadV-A31 annotation of coding regions
Map of the genome organization and transcription units of HAdV-A31....
Phylogenetic analysis of all available complete genomic HAdV sequences...
Global pairwise sequence alignment of the HAdV-A31 genome with...
+1 Schematic view of the predicted E3 CR1 beta (A) and the E3 RID beta (B)...
Unique sequence features of the Human Adenovirus 31 complete genomic sequence conserved in clinical isolates
Article
Full-text available
  • Nov 2009
Human adenoviruses (HAdV) are causing a broad spectrum of diseases. One of the most severe forms of adenovirus infection is a disseminated disease resulting in significant morbidity and mortality. Several reports in recent years have identified HAdV-31 from species A (HAdV-A31) as a cause of disseminated disease in children following haematopoetic...
TABLE 1 . Primer pairs used for amplification and sequencing of the...
FIG. 3. Similarity plots of two subclusters from species HAdV-B (A, B)...
FIG. 4. Lengths of RGD and HVR1 loops for each HAdV type. Boundaries of...
FIG. 6. Early CPE was induced by E. coli -expressed HAdV-D8 penton base...
Phylogenetic Analysis and Structural Predictions of Human Adenovirus Penton Proteins as a Basis for Tissue-Specific Adenovirus Vector Design
Article
Full-text available
  • Sep 2007
The penton base is a major capsid protein of human adenoviruses (HAdV) which forms the vertices of the capsid and interacts with hexon and fiber protein. Two hypervariable loops of the penton are exposed on the capsid surface. Sequences of these and 300 adjacent amino acid residues of all 51 HAdV and closely related simian adenoviruses were studied...
Fig. 1. Phylogenetic trees (neighbour joining) of the nucleic acid...
Fig. 2. Bootscan analysis performed with SimPlot revealed recombination...
Fig. 3. Porcupine molecular-dynamic representation of the fiber...
Phylogeny and Primary Structure Analysis of Fiber Shafts of All Human Adenovirus Types for Rational Design of Adenoviral Gene Therapy Vectors
Article
Full-text available
  • Sep 2009
The fiber shaft of human adenoviruses (HAdVs) is essential for bringing the penton base into proximity to the secondary cellular receptor. Fiber shaft sequences of all 53 HAdV types were studied. Phylogeny of the fiber shaft revealed clustering corresponding to the HAdV species concept. An intraspecies recombination hot spot was found at the shaft/...
Online publication system and method
Patent
Full-text available
  • Aug 2016
Various systems and methods for creating, storing, structuring, displaying, enhancing, and/or referencing publications and related content in an online user network are described. In some embodiments, a plurality of “anchors” are dispersed throughout the document, allowing document portions to be referenced in terms of the anchor(s) associated with...
Unique sequence features of the Adenovirus 31 prototype complete genomic sequence are conserved in clinical isolates from cases of disseminated infection
Conference Paper
Full-text available
  • Jan 2008
Phylogenetic analysis and structural predictions of human adenovirus penton proteins: Basis for tissue specific adenoviral vector design.
Conference Paper
  • Jan 2007
Human adenovirus type 51 penton gene, partial cds
Data
  • Jan 2006
Human adenovirus type 49 penton gene, partial cds
Data
  • Jan 2006
Human adenovirus type 32 penton gene, partial cds
Data
  • Jan 2006
Human adenovirus type 43 penton gene, partial cds
Data
  • Jan 2006
Human adenovirus type 29 penton gene, partial cds
Data
  • Jan 2006
Human adenovirus type 21 penton gene, partial cds
Data
  • Jan 2006
Human adenovirus type 26 penton gene, partial cds
Data
  • Jan 2006
Human adenovirus type 47 penton gene, partial cds
Data
  • Jan 2006
Human adenovirus type 15 penton gene, partial cds
Data
  • Jan 2006
Human adenovirus type 27 penton gene, partial cds
Data
  • Jan 2006
Human adenovirus type 23 penton gene, partial cds
Data
  • Jan 2006
Human adenovirus type 20 penton gene, partial cds
Data
  • Jan 2006
Human adenovirus type 24 penton gene, partial cds
Data
  • Jan 2006
Human adenovirus type 31 penton gene, partial cds
Data
  • Jan 2006
Human adenovirus type 38 penton gene, partial cds
Data
  • Jan 2006
Human adenovirus type 25 penton gene, partial cds
Data
  • Jan 2006
Human adenovirus type 18 penton gene, partial cds
Data
  • Jan 2006
Human adenovirus type 16 penton gene, partial cds
Data
  • Jan 2006
Human adenovirus type 42 penton gene, partial cds
Data
  • Jan 2006
Human adenovirus type 44 penton gene, partial cds
Data
  • Jan 2006
Human adenovirus type 36 penton gene, partial cds
Data
  • Jan 2006
Human adenovirus type 33 penton gene, partial cds
Data
  • Jan 2006
Human adenovirus type 28 penton gene, partial cds
Data
  • Jan 2006
Human adenovirus type 10 penton gene, partial cds
Data
  • Jan 2006
Human adenovirus type 48 penton gene, partial cds
Data
  • Jan 2006
Human adenovirus 1 penton gene, partial cds
Data
  • Jan 2006
Human adenovirus type 19 penton gene, partial cds
Data
  • Jan 2006
Human adenovirus type 39 penton gene, partial cds
Data
  • Jan 2006
Human adenovirus type 45 penton gene, partial cds
Data
  • Jan 2006
Human adenovirus type 22 penton gene, partial cds
Data
  • Jan 2006
Molecular Phylogeny of Main Immunogenic Determinants of all human Adenoviruses: Implications for Molecular Evolution of Human Adenoviruses.
Conference Paper
Full-text available
  • Jan 2006
Molecular Phylogeny of the Penton Protein: Implications for the Molecular Evolution of Human Adenoviruses (HAdV).
Conference Paper
  • Jan 2006

Projects

Project (1)
Molecular Typing of Human Adenoviruses
Archived project
This project was for developing a molecular typing system for human adenoviruses. We identified highly variable gene regions (loop1, loop2 in the hexon gene). Those areas are part of the neutralization properties, in contrary to the fiber gene (hemagglutination properties). Structural Analysis of hexon, fiber and penton were performed in order to enable rational design of adenoviral gene therapy vectors.