Rajnikant Bhikhubhai Mardia

Rajnikant Bhikhubhai Mardia
Dharmsinh Desai University?·?Department of Pharmaceutical Chemistry

10.72
?·?
Doctor of Philosophy

About

17
Publications
49,943
Reads
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43
Citations
Introduction
Dr. Rajnikant Bhikhubhai Mardia currently works as a Senior Assistant Professor at the Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Dharmsinh Desai University. Rajnikant does research in Analytical Chemistry. Their current project is 'Analysis of drugs in bulk and pharmaceutical formulations and biological fluid'. The area of his interest includes bioanalytical and analytical development with degradation and impurity analysis by chromatographic and spectroscopic techniques
Research Experience
July 2010 - present
Dharmsinh Desai University
Position
  • Senior Assistant Professor
Description
  • Teaching UG and PG in Pharmacy
July 2010 - present
Dharmsinh Desai University
Position
  • Senior Assistant Professor
Description
  • PG teacher and Guide
May 2009 - May 2010
Shri leuva Patel trust Pharmacy Mahila College, Amreli, Gujarat, India
Position
  • Lecturer
Description
  • Lecturer in B. Pharm
Education
March 2008 - December 2012
Saurashtra University
Field of study
  • Pharmacy
June 2004 - June 2006
Sardar Patel University
Field of study
  • Master in Pharmacy
June 2000 - April 2004

Publications

Publications (17)
Article
Full-text available
A simple, specific and rapid difference spectroscopic method has been developed for the estimation of Garenoxacin mesylate in bulk and Pharmaceutical formulation. The proposed method was carried out by measuring the difference absorbance of Garenoxacin mesylate in two different conditions containing three different forms of drug generated by neutra...
Article
Full-text available
A simple, specific and rapid difference spectroscopic method has been developed for the estimation of Cidofovir dihydrate in bulk and Pharmaceutical formulation. The proposed method was carried out by measuring the difference absorbance of Cidofovir dihydrate in two different conditions containing three different forms of drug generated by neutral...
Article
Full-text available
A simple, accurate RP-HPLC method has been developed for simultaneous determination of Lopinavir (LPV) and Ritonavir (RTV) from tablet dosage form on reversed phase Brownlee C 18 column. The sample was analyzed using acetonitrile: 10 mM ammonium acetate buffer (pH 4.5): Methanol (40:30:30) as a mobile phase at flow rate of 1.0 ml/min and detection...
Article
Full-text available
A simple, rapid, sensitive and cost effective Difference spectrophotometric method has been developed for the analysis of Epalrestat in bulk and its tablet formulation using two different pH conditions produced by 0.1N HCl (acidic) and 0.1N NaOH (basic). The spectral characteristics of Epalrestat were found to be different in acidic and basic mediu...
Article
Full-text available
Simple, accurate and sensitive spectrophotometric and RP-HPLC methods requiring no prior separation have been developed and validated for simultaneous estimation of Epalrestat and Methylcobalamin in tablet dosage form. The absorption correction method (method: A) is based on direct determination of Epalrestat at 389 nm and Methylcobalamin at 264 nm...
Article
Full-text available
A simple, precise, accurate and repeatable method for bulk and tablet dosage form of Ritonavir have been developed using spectrophotometric method. Differential spectrophotometric method was used. The developed method was validated according to ICH (Q 2 R 1) guidelines and was found to be accurate, precise and specific. Amplitude difference was tak...
Data
Full-text available
The phytochemical analysis was carried out for standardization of fruits of Opuntia elatior Mill. The fruits were preliminary evaluated by estimation of proximate analysis. Presence of betacyanin was confirmed by spectrophotometric and high performance liquid chromatography coupled with mass spectroscopy techniques. The average weight of fruit was...
Article
Simultaneous quantification of Lopinavir and Ritonavir in tablet by HPTLC method was developed and validated. The chromatograms were developed using a mobile phase of Chloroform: 1, 4 - Dioxane (7:3 %v/v) on the pre-coated plate of silica gel GF aluminum TLC plate and quantified by densitometric absorbance mode at 210 nm. The Rf value for lopinavir...
Article
Full-text available
Betalains are of great taxonomic significance in higher plants and occur only in 10 families of the order Caryophyllales (Centrospermae). They are water-soluble nitrogenous pigments. They can be divided into two major structural groups, the red to red-violet betacyanins and the yellow betaxanthins. Betalains are widely used as natural red food colo...
Article
Full-text available
Simultaneous quantification of Lopinavir and Ritonavir in tablet by HPTLC method was developed and validated. The chromatograms were developed using a mobile phase of Chloroform: 1, 4 -Dioxane (7:3 %v/v) on pre-coated plate of silica gel GF aluminum TLC plate and quantified by densitometric absorbance mode at 210 nm. The R f value for lopinavir and...
Article
An attempt has been made to assess the immunomodulatory activity of purified saponin mixture (PSM) isolated from the fruits of Lagenaria siceraria at three dose levels ranging from 50-150 mg/kg body weight in mice using haemagglutination antibody (HA) titre, delayed type hypersensitivity (DTH) and carbon clearance parameters. PSM increased haemaggl...
Article
Full-text available
The method describes simultaneous determination of Mosapride Citrate and Panto-prazole from capsule dosage form. UV spectrophotometric method involves first derivative spectroscopy using 252.10 nm & 302.48 nm as zero crossing points for Mosapride citrate and Pantoprazole respectively. For spectrophotometric method, acetonitrile was used as a solven...
Article
Full-text available
An attempt has been made to assess the immunomodulatory activity of purified saponin mixture (PSM) isolated from the fruits of Lagenaria siceraria at three dose levels ranging from 50-150 mg/kg body weight in mice using haemagglutination antibody (HA) titre, delayed type hypersensitivity (DTH) and carbon clearance parameters. PSM increased haemaggl...
Article
Full-text available
A simple, accurate and reproducible HPLC method, requiring no prior separation, has been developed for the simultaneous estimation of gatifloxaion sesquinydrate (GAT) and ambroxol HCL (AMB) in combined tablet dosage form by using C18-Kromasil 250mmx4.6mm, 5mcm column. The mobile phase was 0.01M Potassium dihydrogen phosphate buffer:acetonitrile(75:...

Questions and Answers

Question & Answers (29)
Question
How to remove toxic heavy metal traces like mercury, lead, cadmium etc. from solid herbal material or food material?
is there any specific methodology or technique to remove metal traces from solid material like food or plant herbal material?
so that after removal of metal, the solid material can be used as food or medicine.
Question
How to confirm metalic co ordinate bond in metal complexes by the NMR spectrum?
What is the effect of co ordinate bond on the chemical shift value of nearby protons?
How it will be predicted in NMR spectrum?
Question
What is the relationship between pKa value and nature oWhat is the range for pKa? What is the conclusion when pka value is negative and above 14?
Some drugs pka is negative and for some molecules pka is above 14.
What is the interpretation of these values of pKa with relation to the nature of the molecules?
Question
CCl4 and CS2 are having dipole moment zero or no dipole. But both are having characteristic vibrational bands in the mid IR range. What can be the reason/s for that?
Question
Phenolic group shows chemical shift delta value below or upto 10 in PMR spectrum due to intermolecular hydrogen bonding in specific solvents but it shifts sometimes upto 15. What can be the reason/s for that?
Question
How the components ?can be retained for 1 min or less time in ?BEH column in UPLC with mobile phase containing 90% acetonitrile? How they can be retained for 1 min ? which can be the possible mechanism?
Question
In some cases hydroxy protons give delta value above 10. So is there any fundamental related to this?

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