Ijad Madisch

Ijad Madisch
ResearchGate | RG

41.29
?·?
Dr. med.

About

109
Publications
618,206
Reads
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879
Citations
Introduction
Hi! I’m Ijad, CEO of ResearchGate, the professional network for scientists. In 2008, I co-founded the network that’s since grown to 17+ million members worldwide. Our mission is to connect the world of science and make research open to all. Prior to ResearchGate, I worked in radiology (high resolution imaging VCT) at Massachusetts General Hospital in Boston, and earned my doctorate in virology (molecular typing of human adenoviruses) while studying CS on the side (never finished it -.- ).
Research Experience
Hannover Medical School
Position
  • Characterisation of a recombinant adenovirus
Harvard University
Position
  • Trabecular Bone Structure Analysis
Description
  • flat panel Volume CT Structural bone parameters
January 2008 - September 2017
ResearchGate
Position
  • CEO
Education
January 2006
Hannover Medical School
Field of study
  • SPSS Introduction Course
January 2005 - February 2020
Massachusetts General Hospital
Field of study
  • Biostatistics Course for Clinical Investigators
March 2002 - October 2008
FernUniversit?t in Hagen
Field of study
  • Computer Science

Publications

Publications (109)
Article
Full-text available
Human adenoviruses (HAdV) are causing a broad spectrum of diseases. One of the most severe forms of adenovirus infection is a disseminated disease resulting in significant morbidity and mortality. Several reports in recent years have identified HAdV-31 from species A (HAdV-A31) as a cause of disseminated disease in children following haematopoetic...
Article
Full-text available
In 2005, a human adenovirus strain (formerly known as HAdV-D22/H8 but renamed here HAdV-D53) was isolated from an outbreak of epidemic keratoconjunctititis (EKC), a disease that is usually caused by HAdV-D8, -D19, or -D37, not HAdV-D22. To date, a complete change of tropism compared to the prototype has never been observed, although apparent recomb...
Article
Full-text available
Human adenoviruses (HAdV) are responsible for a wide spectrum of diseases. The neutralization epsilon determinant (loops 1 and 2) and the hemagglutination gamma determinant are relevant for the taxonomy of HAdV. Precise type identification of HAdV prototypes is crucial for detection of infection chains and epidemiology. epsilon and gamma determinan...
Article
Full-text available
The penton base is a major capsid protein of human adenoviruses (HAdV) which forms the vertices of the capsid and interacts with hexon and fiber protein. Two hypervariable loops of the penton are exposed on the capsid surface. Sequences of these and 300 adjacent amino acid residues of all 51 HAdV and closely related simian adenoviruses were studied...
Article
Traumatic amputation of a thumb with bone loss leaves a patient in severe disability. Reconstructive procedures are restricted by limited shape and have the disadvantage of severe donor-site morbidity. To overcome these limitations, we used a tissue engineering approach to create a distal thumb bone phalanx, combining magnetically sorted 133+ human...
Patent
Full-text available
Various systems and methods for creating, storing, structuring, displaying, enhancing, and/or referencing publications and related content in an online user network are described. In some embodiments, a plurality of “anchors” are dispersed throughout the document, allowing document portions to be referenced in terms of the anchor(s) associated with...
Data
This file is an aligned fasta file including the fiber knob (nucleotide) gene from 51 human adenoviruses (1-51) (Species A-F)
Data
This file is an aligned fasta file including the loop1 area of the hexon (nucleotide) gene from 51 human adenoviruses (1-51) (Species A-F).
Article
Full-text available
The fiber shaft of human adenoviruses (HAdVs) is essential for bringing the penton base into proximity to the secondary cellular receptor. Fiber shaft sequences of all 53 HAdV types were studied. Phylogeny of the fiber shaft revealed clustering corresponding to the HAdV species concept. An intraspecies recombination hot spot was found at the shaft/...
Article
Full-text available
Regenerative technology promises to alleviate the problem of limited donor supply for bone or organ transplants. Most expensive and time consuming is cell expansion in laboratories. We propose a method of magnetically enriched osteoprogenitor stem cells, dispersed in self-assembling hydrogels and applied onto new ultra-high resolution, jet-based, t...
Article
Full-text available
To examine trabecular microarchitecture with high-resolution flat-panel volume computed tomography (CT) and bone mineral density (BMD) with dual-energy x-ray absorptiometry (DXA) in adolescent girls with anorexia nervosa (AN) and to compare these results with those in normal-weight control subjects. The study was approved by the institutional revie...
Article
Full-text available
Gating in small-animal CT imaging can compensate artefacts caused by physiological motion during scanning. However, all published gating approaches for small animals rely on additional hardware to derive the gating signals. In contrast, in this study a novel method of intrinsic respiratory gating of rodents was developed and tested for mice (n=5),...
Article
Ziele: Evaluation einer digitalen Subtraktionstechnik für die Elimination von überlagernden Knochen und Wandverkalkungen. Methode: In 15 Patienten wurde erg?nzend zu einer CT-Angiographie (CTA) eine native Niedrigdosis-Untersuchung durchgeführt. Alle CTA-Untersuchungen erfolgten mit folgendem Scanprotokoll: Schichtkollimation/Rekonstruktionsinkreme...
Article
Full-text available
Availability of grafts and morbidity at the donor site limit autologous transplantation in patients requiring bone reconstruction. A tissue-engineering approach can overcome these limitations by producing bone-like tissue of custom shape and size from isolated cells. Several hydrogels facilitate osteogenesis on porous scaffolds; however, the relati...
Article
Current techniques to measure computed tomography (CT) spatial resolution use separate methods for in-plane and out-of-plane directions. The growing use of near-isotropic voxel size necessitates a new single method that inherently measures resolution in any direction. We introduce a method using a set of numerous glass microspheres suspended in a s...
Article
Full-text available
In a 4-week period, 12 patients contracted adenoviral keratoconjunctivitis. Eight of these patients had visited the same ophthalmologist's practice before onset of symptoms. Adenovirus was detected in swab specimens obtained from 9 patients. Sequence-based typing of 2 isolates revealed type 22/H8. This is, to our knowledge, the first report of a ke...
Article
Human adenovirus (HAdV) infections are increasingly frequent and potentially fatal as a disseminated disease in highly immunocompromised patients. Determining the in vitro sensitivity of HAdV to antiviral agents is not an easy task because HAdV CPE reduction assays are difficult to interpret and may take more than 1 week. We developed a phenotypic...
Article
Precise typing of human adenoviruses (HAdV) is fundamental for epidemiology and the detection of infection chains. As only few of the 51 adenovirus types are associated with life- threatening disseminated diseases in immunodeficient patients, detection of one of these types may have prognostic value and lead to immediate therapeutic intervention. A...
Article
Full-text available
Trabecular bone is a material of choice for reconstruction after trauma and tumor resection and for correction of congenital defects. Autologous bone grafts are available in limited shapes and sizes; significant donor site morbidity is another major disadvantage to this approach. To overcome these limitations, we used a tissue engineering approach...
Data
On or before Apr 6, 2016 this sequence version replaced gi:107954418, gi:107954419, gi:107954417.
Conference Paper
Full-text available
PURPOSE Research in tissue-engineering traditionally relies on protein transcription and expression (PTE) analysis to demonstrate tissue growth. For demonstrating bone growth, mechanical properties of the construct are also used for the same purpose. Using an ultra-high resolution, flat-panel Volume CT (VCT), we demonstrate the first-ever imaging o...
Conference Paper
PURPOSE To propose a standardized and quantitative assessment of image quality and to assess differences between three different image reconstruction protocols for coronary MDCT angiography. METHOD AND MATERIALS We assessed 20 normal coronary segments from two patients who underwent standard coronary MDCT (Siemens Sensation 64, 64x0.6 mm collimati...
Conference Paper
PURPOSE Spatial resolution of a CT scanner is typically characterized by its modulation transfer function and slice selectivity profile. These methods are inherently anisotropic and fail to fully describe the capabilities of recently introduced volume CT scanners (VCT). A new method is required to describe the spatial resolution of VCT that is inhe...